184579-16-6Relevant articles and documents
Enantioselective Alkylation of N-Arylhydrazones Derived from α-Keto Esters and Isatin Derivatives through Asymmetric Phase-Transfer Catalysis
Kang, Qi-Kai,Selvakumar, Sermadurai,Arumugam, Natarajan,Almansour, Abdulrahman I.,Kumar, Raju Suresh,Maruoka, Keiji
, p. 1780 - 1783 (2018)
The phase-transfer-catalyzed asymmetric alkylation reactions of N-arylhydrazones derived from α-keto-esters and isatin derivatives afford enantioenriched azo compounds that bear a tetra-substituted carbon stereocenter in good yields with high chemo- and enantioselectivity. The alkylation products can be readily converted into chiral amino esters, hydrazine derivatives, and aza-β-lactams without loss of enantiopurity.
Oxidation of phenylhydrazones of α-keto esters with hypervalent organoiodine reagents
Barton, Derek H. R.,Jaszberenyi, Joseph Cs.,Shinada, Tetsuro
, p. 7191 - 7194 (2007/10/02)
α-Ketoacids and ketones can easily be regenerated in high yield from their phenylhydrazones via hydroxy azo compounds upon oxidation with hupervalent iodine reagents.
