1846-92-0Relevant articles and documents
Synthesis and selective human monoamine oxidase inhibition of 3-carbonyl, 3-acyl, and 3-carboxyhydrazido coumarin derivatives
Secci, Daniela,Carradori, Simone,Bolasco, Adriana,Chimenti, Paola,Yá?ez, Matilde,Ortuso, Francesco,Alcaro, Stefano
, p. 4846 - 4852 (2011/11/13)
Several 3-carbonyl (1-26), 3-acyl (27-52), and 3-carboxyhydrazido (53-58) coumarins have been synthesized in high yields (72-99%) and tested in vitro for their human monoamine oxidase A and B (hMAO-A and hMAO-B) inhibitory activity. Different substituents on the coumarin nucleus were evaluated for their effect on biological activity and isoform selectivity. Substitution at position C7 of the 3-ethyl ester coumarin ring, or the introduction of a hydrazido substituent at C3, were important to obtain highly potent and selective hMAO-B inhibitors with IC50 values in the nanomolar range. Some derivatives were also submitted to a stability test and showed no chemical cleavage in vitro.
Novel Reactions of Carbon Suboxide. VI. Synthesis of 2-Oxo-1-benzopyran- and 2-Oxoquinoline-3-carboxylic Acid Hydrazides
Bonsignore, Leonardo,Cabiddu, Salvatore,Loy, Giuseppe,Secci, Mario
, p. 463 - 464 (2007/10/02)
A simple, one step synthesis of 2-oxo-1-benzopyran- and 2-oxoquinoline-3-carboxylic acid hydrazides from carbon suboxide and hydrazones is described.
