184652-42-4

Basic information

• Product Name: (2S,3R)-3-benzyloxycarbonylamino-2-hydroxyoctanoic acid
• Synonyms: (2S,3R)-3-benzyloxycarbonylamino-2-hydroxyoctanoic acid
• CAS NO: 184652-42-4
• Molecular Weight: 309.362
• Mol File: 184652-42-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,3R)-3-benzyloxycarbonylamino-2-hydroxyoctanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3R)-3-benzyloxycarbonylamino-2-hydroxyoctanoic acid(184652-42-4)
• EPA Substance Registry System: (2S,3R)-3-benzyloxycarbonylamino-2-hydroxyoctanoic acid(184652-42-4)

Safety Data

• Hazardous Substances Data: 184652-42-4(Hazardous Substances Data)

Upstream product

• 154702-01-9 (2S,3R)-3-amino-2-hydroxyoctanoic acid 
• 42116-21-2 2-benzyloxycarbonylsulfanyl-4,6-dimethyl-pyrimidine 
• 184652-41-3 (4R,5S)-ethyl 2-oxo-4-pentyloxazolidine-5-carboxylate 

Downstream Products

• 184652-46-8 (2S,3R)-3-benzyloxycarbonylamino-2-hydroxyoctanoyl-L-phenylalanine benzyl ester 
• 184652-45-7 (2S,3R)-3-benzyloxycarbonylamino-2-hydroxyoctanoyl-L-leucine benzyl ester 
• 184652-43-5 (2S,3R)-3-benzyloxycarbonylamino-2-hydroxyoctanoyl-L-valine benzyl ester 
• 184652-44-6 (2S,3R)-3-benzyloxycarbonylamino-2-hydroxyoctanoyl-L-alanine benzyl ester 

Relevant articles and documents

Stereospecific synthesis of a novel farnesyl protein transferase inhibitor, valinoctin A and its analogues

(2S,3R)-3-Amino-2-hydroxyoctanoic acid was synthesized by Curtius rearrangement of an azide derivative of (S)-malic acid. Total syntheses of valinoctin A and its analogues were achieved by a coupling of (2S,3R)-3-amino-2-hydroxyoctanoic acid moiety with L-valine or several other amino acids moieties. 2S configuration of 3-amino-2-hydroxyoctanoic acid moiety was found to be important for the inhibitory activity and the L-valine moiety of valinoctin A was exchangeable with other L-amino acids.