184766-59-4Relevant articles and documents
Studies on agents with vasodilator and β-blocking activities. IV
Seki, Toshimi,Nakao, Tomio,Masuda, Takeshi,Hasumi, Kohichi,Gotanda, Kotaro,Ishimori, Tsutomu,Honma, Seijiro,Minami, Nobuyoshi,Shibata, Kenyu,Yasuda, Kikuo
, p. 2061 - 2069 (1996)
A series of novel pyridazinone derivatives (II) having a phenoxypropanolamine moiety was synthesized. Their hypotensive and β- blocking activities were evaluated after intravenous administration of the compounds to anesthetized rats. Among them, the 5-chloro-2-cyanophenoxy derivative (29) showed the promising dual activities and was selected for further studies.