184873-70-9Relevant articles and documents
Chirality induction and chiron approaches to enantioselective total synthesis of α-lipoic acid
Chavan, Subhash P.,Pawar, Kailash P.,Praveen, Ch.,Patil, Niteen B.
supporting information, p. 4213 - 4218 (2015/06/02)
Abstract An efficient, short and convenient asymmetric synthesis of (R)-(+)-lipoic acid in seven steps from chiral hydroxy aldehyde with 32.5% overall yield is described. Synthesis of S and R enantiomers of α-lipoic acid from cis-1,4-butene diol derived chiral lactone is reported with 34 % overall yield. The present synthesis involves use of simple reaction conditions making it a convenient synthesis.
Stereoselective synthesis of (-)-microcarpalide
Chavan, Subhash P.,Praveen, Cherukupally
, p. 1939 - 1941 (2007/10/03)
A highly convergent and efficient synthesis of (-)-microcarpalide, a 10-membered lactone displaying remarkable microfilament disrupting activity is described. Ring-closing metathesis and Sharpless asymmetric dihydroxylations are the key steps. Our strateg
Stereoselective synthesis of microcarpalide
Ishigami, Ken,Watanabe, Hidenori,Kitahara, Takeshi
, p. 7546 - 7553 (2007/10/03)
Microcarpalide is a strong microfilament disrupting agent. The convergent and stereoselective synthesis of microcarpalide was succeeded via Julia olefination and macrolactonization.