185106-16-5

Basic information

• Product Name: AcotiaMide
• Synonyms: AcotiaMide;N-[2-[Bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide;N-(2-(diisopropylamino)ethyl)-2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxamide hydrochloride;Acofide;ACOTIAMIDUM
• CAS NO: 185106-16-5
• Molecular Formula: C21H30N4O5S
• Molecular Weight: 450.5517
• Mol File: 185106-16-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.246g/cm³
• Refractive Index: 1.591
• PKA: 7.38±0.50(Predicted)
• CAS DataBase Reference: AcotiaMide(CAS DataBase Reference)
• NIST Chemistry Reference: AcotiaMide(185106-16-5)
• EPA Substance Registry System: AcotiaMide(185106-16-5)

Safety Data

• Hazardous Substances Data: 185106-16-5(Hazardous Substances Data)

Usage

General Description

Acotiamide is a medication that is primarily used to treat functional dyspepsia, a condition characterized by symptoms such as bloating, nausea, and early satiety. It works by increasing the release of acetylcholine, a neurotransmitter that stimulates the movement of food through the digestive system and enhances gastric emptying. Acotiamide is a unique drug in that it selectively targets the M1 and M2 muscarinic receptors in the gut, without affecting the muscarinic receptors in other parts of the body, which helps to minimize side effects. Studies have shown that acotiamide can effectively reduce dyspeptic symptoms and improve overall quality of life in patients with functional dyspepsia.

InChI:InChI=1/C21H30N4O5S/c1-12(2)25(13(3)4)8-7-22-20(28)15-11-31-21(23-15)24-19(27)14-9-17(29-5)18(30-6)10-16(14)26/h9-13,26H,7-8H2,1-6H3,(H,22,28)(H,23,24,27)

Upstream product

• 121-05-1 N',N'-diisopropyl-ethane-1,2-diamine 
• 490-64-2 asaronic acid 
• 185105-98-0 ethyl 2-[(2,4,5-trimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylate 
• 877997-99-4 2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid methyl ester 
• 5722-93-0 2-hydroxy-4,5-dimethoxybenzoic acid 
• 877997-98-3 2-hydroxy-4,5-dimethoxybenzoic acid phenyl ester 
• 61203-48-3 2-iodo-4,5-dimethoxybenzoic acid 
• 610-90-2 2,4,5-trihydroxybenzoic acid 
• 28373-21-9 2-hydroxy-4,5-dimethoxybenzoic acid methyl ester 
• 7087-68-5 N-ethyl-N,N-diisopropylamine 
• 42833-66-9 2,4,5-trimethoxybenzoyl chloride 

Relevant articles and documents

Industrial production method of acotiamide hydrochloride

The invention discloses an industrial production method of acotiamide hydrochloride. The industrial production method comprises the following steps that firstly, 2,4,5-trimethoxy benzoic acid serves as an initial raw material, acylating chlorination is ca

Method for synthesizing acotiamide hydrochloride

The invention discloses a method for synthesizing acotiamide hydrochloride. According to the method, 2,4,5-trimethoxybenzoic acid, thionyl chloride, methylbenzene, dichloromethane, 2-aminothiazole-4-ethyl formate, N-N-dimethyl formamide, pyridine Hydrochl

Preparing method for acotiamide hydrochloride

The invention relates to a new method for preparing acotiamide hydrochloride. The preparing method includes the following steps that 1, 2-[N-(2,4,5-trimethoxybenzoyl)amino]-4-ethyoxylcarbonyl-1,3-thiazole (a compound in the formula I), di-n-butylamine and