185122-75-2

Basic information

• Product Name: 5H-CYCLOPENTA[B]PYRIDIN-7-AMINE, 6,7-DIHYDRO-
• Synonyms: 5H-CYCLOPENTA[B]PYRIDIN-7-AMINE, 6,7-DIHYDRO-;5H-Cyclopenta[b]pyridin-7-amino,6,7-dihydro-;5H-Cyclopenta[b]pyridin-7-amine,6,7-dihydro-(9CI);6,7-Dihydro-5H-cyclopenta[b]pyridin-7-amine;6,7-Dihydro-5H-[1]pyrindin-7-ylamine
• CAS NO: 185122-75-2
• Molecular Formula: C₈H₁₀N₂
• Molecular Weight: 134.18
• Product Categories: PYRIDINE;Pyridine Derivertives
• Mol File: 185122-75-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 255.243oC at 760 mmHg
• Flash Point: 131.856oC
• Appearance: /
• Density: 1.125g/cm3
• Vapor Pressure: 0.016mmHg at 25°C
• Refractive Index: 1.586
• CAS DataBase Reference: 5H-CYCLOPENTA[B]PYRIDIN-7-AMINE, 6,7-DIHYDRO-(CAS DataBase Reference)
• NIST Chemistry Reference: 5H-CYCLOPENTA[B]PYRIDIN-7-AMINE, 6,7-DIHYDRO-(185122-75-2)
• EPA Substance Registry System: 5H-CYCLOPENTA[B]PYRIDIN-7-AMINE, 6,7-DIHYDRO-(185122-75-2)

Safety Data

• Hazardous Substances Data: 185122-75-2(Hazardous Substances Data)

Usage

General Description

5H-Cyclopenta[b]pyridin-7-amine, 6,7-dihydro- is a chemical compound that belongs to the class of cyclopenta[b]pyridine derivatives. It is a heterocyclic amine with a cyclopentane ring fused to a pyridine ring, and a primary amine group attached at the seventh carbon atom. 5H-CYCLOPENTA[B]PYRIDIN-7-AMINE, 6,7-DIHYDRO- may have potential pharmaceutical applications, as heterocyclic amines are known to possess diverse biological activities, including antifungal, antiviral, and anticancer properties. It may also have potential uses as a building block for the synthesis of more complex chemical compounds. Additionally, its dihydro form suggests a reduced state, which may affect its reactivity and biological activity compared to its fully saturated counterpart. Overall, this chemical compound has the potential to be a valuable tool in drug discovery and development, as well as in medicinal chemistry research.

InChI:InChI=1/C8H10N2/c9-7-4-3-6-2-1-5-10-8(6)7/h1-2,5,7H,3-4,9H2

Upstream product

• 1071727-78-0 5,6-dihydro-[1]pyrindin-7-one O-methyl-oxime 

Downstream Products

• 1228571-16-1 (S)-5H,6H,7H-cyclopenta[b]pyridin-7-amine 
• 298181-96-1 C₂₈H₂₇N₅O₄S 
• 1228571-16-1 (R)-6,7-dihydro-5H-cyclopenta[b]pyridin-7-amine 

Relevant articles and documents

Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication

The redesign of azamacrocyclic CXCR4 chemokine receptor antagonists resulted in the discovery of novel, small molecule, orally bioavailable compounds that retained T-tropic (CXCR4 using, X4) anti-HIV-1 activity. A structure-activity relationship (SAR) was determined on the basis of the inhibition of replication of X4 HIV-1 NL4.3 in MT-4 cells. As a result of lead optimization, we identified (S)-N′-((1H-benzo[d]imidazol-2-yl)methyl)- N′-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine (AMD070) 2 as a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay. Compound 2 inhibited the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with an IC50 of 2 and 26 nM, respectively, while remaining noncytotoxic to cells at concentrations exceeding 23 μM. The pharmacokinetics of 2 was evaluated in rat and dog, and good oral bioavailability was observed in both species. This compound represents the first small molecule orally bioavailable CXCR4 antagonist that was developed for the treatment of HIV-1 infection.

SUBSTITUTED FLUOROETHYL UREAS AS ALPHA 2 ADRENERGIC AGENTS

Therapeutic compounds, and methods, compositions, and medicaments related thereto are disclosed herein.

Substituted aryl 1,4-pyrazine derivatives

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