18524-18-0

Basic information

• Product Name: (3R,4R)-4,5-ISOPROPYLIDENE PENT-2-EN-3-OL
• Synonyms: (3R,4R)-4,5-ISOPROPYLIDENE PENT-2-EN-3-OL;1-((R)-2,2-DIMETHYL-1,3-DIOXOLAN-4-YL)PROP-2-EN-1-OL;1,2-dideoxy-4,5-O-(1-Methylethylidene)-D-threo-Pent-1-enito
• CAS NO: 18524-18-0
• Molecular Formula: C₈H₁₄O₃
• Molecular Weight: 158.19
• Mol File: 18524-18-0.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 215.1°Cat760mmHg
• Flash Point: 100.2°C
• Appearance: /
• Density: 1.027g/cm³
• Vapor Pressure: 0.033mmHg at 25°C
• Refractive Index: 1.452
• CAS DataBase Reference: (3R,4R)-4,5-ISOPROPYLIDENE PENT-2-EN-3-OL(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,4R)-4,5-ISOPROPYLIDENE PENT-2-EN-3-OL(18524-18-0)
• EPA Substance Registry System: (3R,4R)-4,5-ISOPROPYLIDENE PENT-2-EN-3-OL(18524-18-0)

Safety Data

• Hazardous Substances Data: 18524-18-0(Hazardous Substances Data)

Usage

Description

(3R,4R)-4,5-ISOPROPYLIDENE PENT-2-EN-3-OL is a chiral colorless liquid chemical compound with the molecular formula C8H14O. It has two stereocenters and is commonly used as an intermediate in the synthesis of various organic compounds.

Uses

Used in Pharmaceutical Industry:
(3R,4R)-4,5-ISOPROPYLIDENE PENT-2-EN-3-OL is used as an intermediate in the production of pharmaceuticals due to its unique chiral structure and reactivity in organic synthesis reactions.
Used in Perfume Industry:
(3R,4R)-4,5-ISOPROPYLIDENE PENT-2-EN-3-OL is used as a key component in the synthesis of various perfumes and fragrances, contributing to their unique scents and properties.
Used in Chemical Industry:
(3R,4R)-4,5-ISOPROPYLIDENE PENT-2-EN-3-OL is used as a reagent in organic synthesis reactions, enabling the production of a wide range of chemicals and materials.
Used in Specialty Polymers and Materials Production:
(3R,4R)-4,5-ISOPROPYLIDENE PENT-2-EN-3-OL has potential applications in the production of specialty polymers and materials, where its unique properties can be utilized to create innovative and high-performance products.

InChI:InChI=1/C8H14O3/c1-4-6(9)7-5-10-8(2,3)11-7/h4,6-7,9H,1,5H2,2-3H3/t6-,7-/m1/s1

Upstream product

• 1826-67-1 vinyl magnesium bromide 
• 15186-48-8 2,3-isopropylidene-glyceraldehyde 
• 109836-16-0 1-iodo-1-deoxy-2,3:4,5-di-O-isopropylidene-D-xylitol 
• 102418-34-8 1,2:5,6-bis-O-(1-methylethylidene)-D-mannitol 
• 143706-60-9 (2R)-3-O-acetyl-1,2-O-isopropylidene-5-(trimethylsilyl)-4-pentyne-1,2,3-triol 
• 362032-94-8 1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3-(trimethylsilyl)prop-2-yn-1-ol 
• 30737-85-0 2,3,4,5-di-O-isopropylidene-D-xylitol 
• 13039-94-6 2,3,4,5-di-O-isopropylidene-D-xylose aldehyde 
• 143706-60-9 (2R,3R)-3-O-acetyl-1,2-O-isopropylidene-5-(trimethylsilyl)-4-pentyne-1,2,3-triol 
• 143788-59-4 (2R,3S)-1,2-O-isopropylidene-5-(trimethylsilyl)-4-pentyne-1,2,3-triol 
• 170028-87-2 D-xylose-(2R,3R,4R)-5-di-O-isopropylidene-[4-(methylphenyl)sulfonyl]hydrazone 
• 102357-25-5 (1S,4'R)-1-(2,2-dimethyl-1,3-dioxolane-4-yl)-2-trimethylsilylprop-2-en-1-ol 
• 71769-39-6 (4S,5S,4'R)-5-Iodomethyl-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl] 
• 4957-71-5 (+)-(2R,3R)-1,2-O-isopropylidene-4-pentyne-1,2,3-triol 

Downstream Products

• 1374646-35-1 (R,E)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-(3-nitrophenoxy)but-2-en-1-ol 
• 303158-64-7 (E)-(R)-4-(tert-Butyl-diphenyl-silanyloxy)-4-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methyl-but-2-enoic acid ethyl ester 
• 303158-52-3 tert-Butyl-[(E)-(R)-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-methoxymethoxy-3-methyl-but-2-enyloxy]-diphenyl-silane 
• 303158-65-8 (E)-(R)-4-(tert-Butyl-diphenyl-silanyloxy)-4-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methyl-but-2-en-1-ol 
• 303158-51-2 (S)-(tert-Butyl-diphenyl-silanyloxy)-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-acetaldehyde 
• 289666-92-8 (+)-methyl (3S,4R,5R,6R)-5-benzyloxy-7-tert-butyldiphenylsilyloxy-2,2-dimethyl-4,6-methylenedioxy-3-trimethylsilyloxyheptanoate 
• 289666-93-9 (-)-methyl (3S,4R,5R,6R)-5-benzyloxy-7-tert-butyldiphenylsilyloxy-2,2-dimethyl-3-hydroxy-4,6-methylenedioxy-heptanoate 
• 289667-10-3 (+)-methyl (3S,4R,5R,6R)-5-benzyloxy-7-tert-butyldiphenylsilyloxy-2,2-dimethyl-3-methoxy-4,6-methylenedioxy-heptanoate 
• 289667-09-0 (+)-(3S,4R,5R,6R)-5-benzyloxy-7-tert-butyldiphenylsilyloxy-2,2-dimethyl-3-methoxy-4,6-methylenedioxyheptanol 
• 289666-89-3 (-)-(2R,3S,4R)-3-benzyloxy-1-tert-butyldiphenylsilyloxy-2,4-dihydroxypentan-5-yl pivalate 
• 289666-87-1 (+)-(2S,3R,4R)-3-benzyloxy-5-tert-butyldiphenylsilyloxy-2,4-methylenedioxypentanal 
• 289667-02-3 (+)-(4S,5R,6R,7R)-6-benzyloxy-8-tert-butyldiphenylsilyloxy-3,3-dimethyl-4-methoxy-5,7-methylenedioxyoctyl-1-ene 
• 289666-94-0 (+)-(3S,4R,5R,6R)-5-benzyloxy-7-tert-butyldiphenylsilyloxy-2,2-dimethyl-3-methoxy-4,6-methylenedioxyheptanal 
• 289667-00-1 (+)-(1R,5R,6R,8R,10S)-5-(tert-butyldiphenylsilyloxy)methyl-9,9-dimethyl-10-methoxy-8-(prop-2-enyl)-2,4,7-trioxabicyclo[4.4.0]decane 

Relevant articles and documents

Synthesis of Fluorinated Amides Starting from Carbohydrates Based on the Claisen Rearrangement

The search for new methods for installation of fluorine atoms into organic molecules is still a widely studied issue. In this work, an efficient synthetic protocol for the synthesis of fluorine-containing amides derived from sugar has been presented. This approach involved the Claisen rearrangement of previously obtained fluorinated vinyl ethers. The three fluorinated olefins: 1,1,3,3,3-pentafluoroprop-1-ene (2H-PFP), 1,2,3,3,3-pentafluoroprop-1-ene (1H-PFP) and hexafluoroprop-1-ene (HFP) were used as a source of fluorine. New compounds were characterized by 1H, 19F and 13C NMR spectroscopy and high resolution mass spectrometry. The X-ray crystal structures of some fluorinated derivatives were obtained confirming structure, geometry and absolute configuration. The resulting molecules, due to possibility of further transformation of their functional groups, can be valuable fluorinated scaffolds for the synthesis of subsequent chemical compounds.

Synthesis of polyhydroxylated decalins via two consecutive one-pot reactions: 1,4-Addition/aldol reaction followed by RCM/syn-dihydroxylation

Synthesis of novel polyhydroxylated derivatives of decalin is described. The presented methodology consists in a one-pot copper-catalyzed 1,4-addition of vinylmagnesium bromide to sugar-derived cyclohexenone, followed by an aldol reaction with a derivativ

PROCESS FOR PREPARING NEBIVOLOL

The present invention relates to a process for preparing nebivolol and, more particularly, to a process for preparing d-nebivolol and its enantiomer /-nebivolol or acid addition salts thereof starting from commercially available or easily obtainable 2,2-dimethyl-l,3 dioxolane-4- carbaldehyde and a vinyl Grignard reagent.