185411-12-5 Usage
Description
METHYL 3-(TRIMETHYLSILYL)-4-PENTENOATE is an organic compound that serves as an essential intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its unique structure, which includes a trimethylsilyl group and a pentenoate functional group, making it a versatile building block in organic synthesis.
Uses
Used in Pharmaceutical Synthesis:
METHYL 3-(TRIMETHYLSILYL)-4-PENTENOATE is used as a key intermediate in the synthesis of Eribulin (E615203), a synthetic analog of the marine natural product halichondrin B. Eribulin is a potent microtubule dynamics inhibitor that has been approved for the treatment of certain types of cancer, including metastatic breast cancer and liposarcoma.
In the pharmaceutical industry, METHYL 3-(TRIMETHYLSILYL)-4-PENTENOATE plays a crucial role in the development of novel therapeutic agents, particularly in the area of cancer treatment. Its unique chemical properties allow for the creation of complex molecular structures that can target specific biological pathways, making it a valuable asset in the ongoing search for new and effective cancer treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 185411-12-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,5,4,1 and 1 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 185411-12:
(8*1)+(7*8)+(6*5)+(5*4)+(4*1)+(3*1)+(2*1)+(1*2)=125
125 % 10 = 5
So 185411-12-5 is a valid CAS Registry Number.
InChI:InChI=1/C9H18O2Si/c1-6-8(12(3,4)5)7-9(10)11-2/h6,8H,1,7H2,2-5H3
185411-12-5Relevant articles and documents
Synthetic studies on halichondrins: A practical synthesis of the C.1-C.13 segment
Stamos, Dean P.,Kishi, Yoshito
, p. 8643 - 8646 (1996)
A practical, scalable synthesis of the C.1-C.13 segment of halichondrin B has been developed starting from L-mannonic-γ-lactone, using C-allylation/oxy-Michael cyclization and Ni(II)/Cr(II)-mediated vinyltrimethylsilane addition to set the C.6/C.3 and C.11 stereocenters, respectively.
