185459-32-9Relevant articles and documents
A practical synthesis of 4′-methylbiphenyl-2-carbonitrile as a key intermediate of angiotensin II antagonists
Noda, Yumiki,Akiba, Yoshikazu,Kashima, Mikito
, p. 4633 - 4639 (2007/10/03)
A new and practical synthesis of 4′-methylbiphenyl-2-carbonitrile, a key intermediate of angiotensin II antagonists is described. The key step is Pd-catalyzed dehydrogenation of the compound 6, which proceeds selectively by utilizing hydrogen acceptor such as maleic diester or oxygen.