18546-13-9Relevant articles and documents
Krasso,Weiss
, p. 1113,1116 (1966)
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Reber,Reichstein
, p. 343,350 (1946)
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Cardenolide and Steroid Glycosides from Alafia sp., an Antimalarial Plant from Madagascar
Rakotondramanga,Raharisololalao,Rakotoarimanga,Krebs, H. Ch.,Rasoanaivo,Razakarivony,Randrianasolo
, (2016)
New cardenolide glycoside 1 and steroid glycoside 2, named respectively corotoxigenin-3-O-β- digitalopyranosyl-(1–4)-O-β-digitoxopyanoside and 5?-pregnene-3β,16α,20(S)-diol 20-O-[β-Ddigitalopyranosyl (1→2)-β-D-glucopyranoside], have been isolated from the
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Muhr et al.
, p. 403,408 (1954)
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Bhattacharjee,Timell
, p. 758,764 (1965)
A novel low-molecular-mass pumpkin polysaccharide: Structural characterization, antioxidant activity, and hypoglycemic potential
Huang, Linlin,Li, Fei,Li, Quanhong,Liang, Li,Wei, Yunlu,Yu, Guoyong
, (2020/10/02)
The novel natural low-molecular-mass polysaccharide (SLWPP-3) from pumpkin (Cucurbia moschata) was separated from the waste supernatant after macromolecular polysaccharide production and purified using a DEAE cellulose-52 column and gel-filtration chromatography. Chemical and instrumental studies revealed that SLWPP-3 with a molecular mass of 3.5 kDa was composed of rhamnose, glucose, arabinose, galactose and uronic acid with a weight ratio of 1: 1: 4: 6: 15, and primarily contained →3,6)-β-D-Galp-(1→, →4)-α-GalpA-(1→(OMe), →4)-α-GalpA-(1→, →2,4)-α-D-Rhap-(1→, →3)-β-D-Galp-(1→, →4)-α-D-Glcp, and →4)-β-D-Galp residues in the backbone. The branch chain passes were connected to the main chain through the O-4 atom of glucose and O-3 atom of arabinose. Physiologically, the ability of SLWPP-3 to inhibit carbohydrate-digesting enzymes and DPPH and ABTS radicals, as well as protect pancreatic β cells from oxidative damage by decreasing MDA levels and increasing SOD activities, was confirmed. The findings elucidated the structural types of pumpkin polysaccharides and revealed a potential adjuvant natural product with hypoglycemic effects.
Pregnane glycosides from Gymnema inodorum and their α-glucosidase inhibitory activity
Trang, Do Thi,Yen, Duong Thi Hai,Cuong, Nguyen The,Anh, Luu The,Hoai, Nguyen Thi,Tai, Bui Huu,Doan, Vu Van,Yen, Pham Hai,Quang, Tran Hong,Nhiem, Nguyen Xuan,Minh, Chau Van,Kiem, Phan Van
, p. 2157 - 2163 (2019/11/03)
Two new pregnane glycosides, gyminosides A and B (1 and 2) and three known, tinctoroside B (3), tinctoroside C (4), and gymnepregoside F (5) were isolated from the leaves of Gymnema inodorum (Lour.) Decne. Their structures were elucidated by physical and chemical methods and comparing with those reported in the literature. All these compounds were evaluated for α-glucosidase assay. Compound 5 exhibited the most anti α-glucosidase activity with inhibitory percentage of 63.7 ± 3.9% at the concentration of 200 μM. Compounds 1–4 showed moderate anti α-glucosidase activity with inhibitory percentage ranging from 40.0 to 52.1%.
Five new pregnane glycosides from Gymnema sylvestre and their α-glucosidase and &alphla;-amylase inhibitory activities
Kim, Seung Hyun,Kim, Sun Yeou,Lee, Jae Hyuk,Ngoc, Tran Minh,Nhiem, Nguyen Xuan,Park, Seon Ju,Tai, Bui Huu,Trang, Do Thi,Van Hung, Nguyen,Van Kiem, Phan,Van Minh, Chau,Yen, Duong Thi Hai,Yen, Pham Hai
, (2020/07/09)
Gymnema sylvestre, a medicinal plant, has been used in Indian ayurvedic traditional medicine for the treatment of diabetes. Phytochemical investigation of Gymnema sylvestre led to the isolation of five new pregnane glycosides, gymsylosides A-E (1-5) and four known oleanane saponins, 3β-O-β-D-glucopyranosyl (1→6)-β-D-glucopyranosyl oleanolic acid 28-O-β-D-glucopyranosyl ester (6), gymnemoside-W1 (7), 3β-O-β-D-xylopyranosyl-(1→6)-β-Dglucopyranosyl-(1→6)-β-D-glucopyranosyl oleanolic acid 28-O-β-D-glucopyranosyl ester (8), and alternoside XIX (9). Their structures were identified based on spectroscopic evidence and comparison with those reported in the literature. All compounds were evaluated for their α-glucosidase and α-amylase inhibitory activities. Compounds 2-4 showed significant α-amylase inhibitory activity, with IC50 values ranging from 113.0 to 176.2 μM.