185532-47-2

Basic information

• Product Name: Benzenesulfonamide, N,N'-1,4-butanediylbis[2,4,6-trimethyl-N-[1-[(2,4,6-trimethylphenyl)sulfon yl]-4-piperidinyl]-
• CAS NO: 185532-47-2
• Molecular Formula: C50H70N4O8S4
• Molecular Weight: 983.392
• Mol File: 185532-47-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, N,N'-1,4-butanediylbis[2,4,6-trimethyl-N-[1-[(2,4,6-trimethylphenyl)sulfon yl]-4-piperidinyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, N,N'-1,4-butanediylbis[2,4,6-trimethyl-N-[1-[(2,4,6-trimethylphenyl)sulfon yl]-4-piperidinyl]-(185532-47-2)
• EPA Substance Registry System: Benzenesulfonamide, N,N'-1,4-butanediylbis[2,4,6-trimethyl-N-[1-[(2,4,6-trimethylphenyl)sulfon yl]-4-piperidinyl]-(185532-47-2)

Safety Data

• Hazardous Substances Data: 185532-47-2(Hazardous Substances Data)

Usage

General Description

Benzenesulfonamide, N,N'-1,4-butanediylbis[2,4,6-trimethyl-N-[1-[(2,4,6-trimethylphenyl)sulfonyl]-4-piperidinyl]-" is a complex chemical compound that contains both sulfonamide and piperidine groups. It is a derivative of benzenesulfonamide and is characterized by a butanediyl bridge connecting two sulfonamide groups, each of which is further substituted with trimethyl groups. The piperidine group is also substituted with trimethylphenylsulfonyl group. It is often used as a stabilizer and UV absorber in various products, including plastics and polymers. Benzenesulfonamide, N,N'-1,4-butanediylbis[2,4,6-trimethyl-N-[1-[(2,4,6-trimethylphenyl)sulfon yl]-4-piperidinyl]- is known for its ability to improve the durability and performance of materials, making it an important ingredient in the manufacturing of various industrial and consumer products.

Upstream product

• 628-21-7 1,4-Diiodobutane 
• 185532-45-0 2,4,6-Trimethyl-N-[1-(2,4,6-trimethyl-benzenesulfonyl)-piperidin-4-yl]-benzenesulfonamide 
• 35621-01-3 4-aminopiperidine dihydrochloride 
• 773-64-8 2-mesitylenesulphonyl chloride 

Relevant articles and documents

Polyamine analogue regulation of NMDA MK-801 binding: A structure-activity study

A series of analogues and homologues of spermine were synthesized, and their impact on MK-801 binding to the N-methyl-D-aspartate (NMDA) receptor was evaluated. These tetraamines encompass both linear and cyclic compounds. The linear molecules include norspermine, N1,N11-diethylnorspermine, N1,N12-bis(2,2,2-trifluoroethyl)spermine, homospermine, and N1,N14-diethylhomospermine. The cyclic tetraamines consist of the piperidine analogues N1,N3-bis(4-piperidinyl)-1,3-diaminopropane, N1,N4-bis(4-piperidinyl)-1,4-diaminobutane, N1,N4-bis(4-piperidinylmethyl)-1,4-diaminobutane, and N1,N4-bis[2-(4-piperidinyl)ethyl]-1,4-diaminobutane and the pyridine analogues N1,N3-bis(4-pyridyl)-1,3-diaminopropane, N1,N4-bis(4-pyridyl)-1,4-diaminobutane, N1,N4-bis(4-pyridylmethyl)-1,4-diaminobutane, and N1,N4-bis[2-(4-pyridyl)-ethyl]-1,4-diaminobutane. This structure-activity set makes it possible to establish the importance of charge, intercharge distance, and terminal nitrogen substitution on polyamine-regulated MK-801 binding in the NMDA channel. Four families of tetraamines are included in this set: norspermines, spermines, homospermines, and tetraazaoctadecanes. Calculations employing a SYBYL modeling program revealed that the distance between terminal nitrogens ranges between 12.62 and 19.61 ?. The tetraamines are constructed such that within families cyclics and acyclics have similar lengths but different nitrogen pKa's and thus different protonation, or charge, states at physiological pH. The pKa values for all nitrogens of each molecule and its protonation state at physiological pH are described. The modifications at the terminal nitrogens include introduction of ethyl and β,β,β-trifluoroethyl groups and incorporation into piperidinyl or pyridyl systems. The studies clearly indicate that polyamine length, charge, and terminal nitrogen substitution have a significant effect on how the tetraamine regulates MK-801 binding to the NMDA receptor. Thus a structure-activity basis set on which future design of MK-801 agonists and antagonists can be based is now available.