18631-22-6

Basic information

• Product Name: 5H-Indeno[1,2-c]pyridin-5-one
• Synonyms: 5H-Indeno[1,2-c]pyridin-5-one;3-Azafluorene-9-one;3-Azafluoren-9-one;3-Azafluorenone
• CAS NO: 18631-22-6
• Molecular Formula: C₁₂H₇NO
• Molecular Weight: 181.1901
• Mol File: 18631-22-6.mol
• Article Data: 9

Chemical Properties

• Melting Point: 129-130℃
• Boiling Point: 361 °C at 760 mmHg
• Flash Point: 179.8 °C
• Appearance: /
• Density: 1.312 g/cm³
• Vapor Pressure: 2.14E-05mmHg at 25°C
• Refractive Index: 1.677
• CAS DataBase Reference: 5H-Indeno[1,2-c]pyridin-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5H-Indeno[1,2-c]pyridin-5-one(18631-22-6)
• EPA Substance Registry System: 5H-Indeno[1,2-c]pyridin-5-one(18631-22-6)

Safety Data

• Hazardous Substances Data: 18631-22-6(Hazardous Substances Data)

Usage

General Description

5H-Indeno[1,2-c]pyridin-5-one is a chemical compound with the molecular formula C13H9NO. It belongs to the class of indeno[1,2-c]pyridine compounds, which are known for their diverse biological activities. 5H-Indeno[1,2-c]pyridin-5-one has been studied for its potential applications in drug discovery and medicinal chemistry, particularly in the treatment of cancer and other diseases. It has been found to exhibit interesting pharmacological properties, and research is ongoing to explore its therapeutic potential. The unique structure of 5H-Indeno[1,2-c]pyridin-5-one makes it a promising candidate for the development of novel pharmaceuticals and therapeutic agents.

InChI:InChI=1/C12H7NO/c14-12-9-4-2-1-3-8(9)11-7-13-6-5-10(11)12/h1-7H

Upstream product

• 91973-39-6 (2-Aminophenyl)-(pyridin-4-yl)methanone 
• 244-42-8 3-azafluorene 
• 104096-15-3 3-phenylpyridine-4-carboxylic acid 
• 103681-95-4 N,N-diisopropyl 2-(3-pyridyl)benzamide 
• 90395-44-1 1-(2-pyridin-3-yl-phenyl)-ethanone 
• 308103-40-4 (2-acetylphenyl)boronic acid 
• 626-55-1 3-Bromopyridine 
• 3430-22-6 3-Bromo-4-methylpyridin 
• 244205-40-1 (2-bromophenyl)boronic acid 
• 13959-02-9 3-bromoisonicotinic acid 
• 583-55-1 1-Bromo-2-iodobenzene 
• 70201-43-3 3-bromo-pyridine-4-carbaldehyde 
• 122-78-1 phenylacetaldehyde 
• 60-12-8 2-phenylethanol 

Downstream Products

• 110576-18-6 3-Azafluorene-9-one semicarbazone 
• 850162-90-2 3-aza-9-hydroxy-9-fluorenylcarbonyl-L-prolyl-2-(tert-butyloxycarbonylaminomethyl)-5-chlorobenzylamide 

Relevant articles and documents

On the mechanism of the metalation of 2-(pyridin-3-yl)benzoic acid derivatives

The mechanism of the metalation of 2-(pyridin-3-yl)benzoic acid derivatives with strong bases is discussed.

Scope of regioselective Suzuki reactions in the synthesis of arylpyridines and benzylpyridines and subsequent intramolecular cyclizations to azafluorenes and azafluorenones

The current investigation on regioselective Suzuki reactions of 2,3-dihalopyridines and 2-halo-3-halomethylpyridines yielded the unexplored synthesis of arylpyridines and benzylpyridines bearing synthetic handles for further functionalization. Indeed, the scope of intramolecular cyclizations of arylpyridines and benzylpyridines prepared in this study for the synthesis of azafluorenes and azafluorenones has been investigated.

Palladium-catalyzed synthesis of fluoreones from bis(2-bromophenyl)methanols

A palladium-catalyzed synthesis method of fluorenones has been developed. A variety of bis(2-bromophenyl)methanols could undergo the reaction smoothly in the presence of Pd(OAc)2, affording a series of fluorenones in moderate to good yields (two steps). Mechanistic studies reveal that the reaction might be triggered by oxidation of alcohol followed by intramolecular reductive coupling.

Aza-spirobifluorene derivative and preparation method thereof

The invention discloses an aza-spirobifluorene derivative. The aza-spirobifluorene derivative is characterized by having a structural formula as shown in the specification, wherein only one of X1, X2, X3 and X4 is a nitrogen atom, and the other three are carbon atoms; and R is an aromatic or heterocyclic aromatic ring containing 6-60 carbon atoms. The aza-spirobifluorene derivative disclosed by the invention can be used as an illuminant material; the aza-spirobifluorene derivative can be independently used as an illuminating layer or doped dye for illuminating or can be formed into an exciplex with the other materials for illuminating; the aza-spirobifluorene derivative also has a carrier transporting capacity; and a group has a hole transmitting capacity and an electron transmitting capacity. The aza-spirobifluorene derivative provided by the invention can be prepared into an excellent amorphous film according to vacuum evaporation or solution methods (spin coating, printing, and the like). The aza-spirobifluorene derivative also has higher thermal stability and photo-stability.