186343-35-1

Basic information

• Product Name: (S)-5-phenyl-1,3-oxazolidine-2-one
• Synonyms: (S)-5-phenyl-1,3-oxazolidine-2-one
• CAS NO: 186343-35-1
• Molecular Weight: 163.176
• Mol File: 186343-35-1.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: (S)-5-phenyl-1,3-oxazolidine-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-5-phenyl-1,3-oxazolidine-2-one(186343-35-1)
• EPA Substance Registry System: (S)-5-phenyl-1,3-oxazolidine-2-one(186343-35-1)

Safety Data

• Hazardous Substances Data: 186343-35-1(Hazardous Substances Data)

Upstream product

• 86013-50-5 (R)-(2-hydroxy-2-phenyl-ethyl)carbamic acid tert-butyl ester 
• 124-38-9 carbon dioxide 
• 124817-06-7 (S)-2-azido-1-phenylethanol 
• 96-09-3 styrene oxide 
• 917-61-3 sodium isocyanate 
• 20780-54-5 (S)-styrene oxide 
• 100-42-5 styrene 
• 56613-81-1 (S)-2-Amino-1-phenyl-1-ethanol 
• 530-62-1 1,1'-carbonyldiimidazole 
• 100-52-7 benzaldehyde 
• 141377-54-0 2-nitro-1-phenylethan-1-ol 
• 7568-93-6 2-Amino-1-phenylethanol 
• 136354-01-3 N-methoxycarbonyl-1-methoxy-2-phenylethylamine 
• 73885-72-0 trans-N-methoxycarbonyl-2-phenylethenylamine 

Downstream Products

• 56613-81-1 (S)-2-Amino-1-phenyl-1-ethanol 
• 14769-73-4 Levamisole 
• 112790-83-7 (S)-3-(2'-hydroxy-2'-phenylethyl)-2-thiazolidinimine 
• 848186-80-1 (S)-2-((tert-butyldimethylsilyl)oxy)-2-phenylethanamine 
• 848186-81-2 N-(2-chloroethyl)-2-tert-butyldimethylsilyloxy-2-phenylethanamine 
• 177697-55-1 (4S)-4-phenyl-3-[(2R)-2-phenylpropionyl]oxazolidin-2-one 
• 189028-93-1 (S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione 
• 281670-47-1 (S)-(2-hydroxy-2-phenyl-ethyl)carbamic acid tert-butyl ester 

Relevant articles and documents

Stereoselective Synthesis of Enantiopure Oxazolidinones via Biocatalytic Asymmetric Aminohydroxylation of Alkenes

Chiral oxazolidinones are of significance in both medicinal and synthetic chemistry, while preparing these compounds usually involves using expensive starting materials and harsh reaction conditions. Herein, a one-pot biocatalytic cascade process was developed for stereo- and regioselective aminohydroxylation of diverse alkenes by combining styrene monooxygenase and halohydrin dehalogenase, providing an approach to enantiopure oxazolidinones. (Figure presented.).

Synthesis of Chiral 5-Aryl-2-oxazolidinones via Halohydrin Dehalogenase-Catalyzed Enantio- and Regioselective Ring-Opening of Styrene Oxides

An efficient biocatalytic approach for enantio- and regioselective ring-opening of styrene oxides with cyanate was developed by using the halohydrin dehalogenase HheC from Agrobacterium radiobacter AD1, generating the corresponding chiral 5-aryl-2-oxazoli

Kinetic resolution of racemic amino alcohols through intermolecular acetalization catalyzed by a chiral Bronsted acid

The kinetic resolution of racemic secondary alcohols is a fundamental method for obtaining enantiomerically enriched alcohols. Compared to esterification, which is a well-established method for this purpose, kinetic resolution through enantioselective intermolecular acetalization has not been reported to date despite the fact that the formation of acetals is widely adopted to protect hydroxy groups. By taking advantage of the thermodynamics of acetalization by the addition of alcohols to enol ethers, a highly efficient kinetic resolution of racemic amino alcohols was achieved for the first time and in a practical manner using a chiral phosphoric acid catalyst.