186422-32-2

Basic information

• Product Name: C₃₀H₂₇N₃
• Synonyms: C₃₀H₂₇N₃
• CAS NO: 186422-32-2
• Molecular Weight: 429.564
• Mol File: 186422-32-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₃₀H₂₇N₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₀H₂₇N₃(186422-32-2)
• EPA Substance Registry System: C₃₀H₂₇N₃(186422-32-2)

Safety Data

• Hazardous Substances Data: 186422-32-2(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 33016-47-6 (1-tritylimidazol-4-yl)carboxaldehyde 

Relevant articles and documents

The discovery of potent inhibitors of aldosterone synthase that exhibit selectivity over 11-β-hydroxylase

Aldosterone, the final component of the renin-angiotensin-aldosterone system, plays an important role in the pathophysiology of hypertension and congestive heart failure. Aldosterone synthase (CYP11B2) catalyzes the last three steps of aldosterone biosynthesis, and as such appears to be a target for the treatment of these disorders. A sulfonamide-imidazole scaffold has proven to be a potent inhibitor of CYP11B2. Furthermore, this scaffold can achieve high levels of selectivity for CYP11B2 over CYP11B1, a key enzyme in the biosynthesis of cortisol.

Novel farnesyl protein transferase inhibitors as antitumor agents

Disclosed are novel tricyclic compounds represented by the formula (1.0): or a pharmaceutically acceptable salt or solvate thereof. The compounds are useful for inhibiting farnesyl protein transferase. Also disclosed are pharmaceutical compositions comprising compounds of formula 1.0. Also disclosed are methods of treating cancer using the compounds of formula 1.0.