18654-73-4

Basic information

• Product Name: Benzene, 1-(1E)-1-butenyl-4-chloro-
• CAS NO: 18654-73-4
• Molecular Formula: C10H11Cl
• Molecular Weight: 166.65
• Mol File: 18654-73-4.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(1E)-1-butenyl-4-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(1E)-1-butenyl-4-chloro-(18654-73-4)
• EPA Substance Registry System: Benzene, 1-(1E)-1-butenyl-4-chloro-(18654-73-4)

Safety Data

• Hazardous Substances Data: 18654-73-4(Hazardous Substances Data)

Upstream product

• 3047-24-3 4-(p-chlorophenyl)-1-butene 
• 103979-29-9 (E)-1-(4-chlorophenyl)-3-chloropropene 
• 75-16-1 methylmagnesium bromide 
• 97-94-9 triethyl borane 
• 101671-01-6 1-nitro-2-(4-chlorophenyl)ethylene 
• 5271-36-3 P,P-diethyldibenzophospholium iodide 
• 104-88-1 4-chlorobenzaldehyde 
• 13856-86-5 1-(4-chlorophenyl)butan-1-ol 
• 4981-63-9 4-n-butanoylchlorobenzene 
• 123-72-8 butyraldehyde 
• 108-90-7 chlorobenzene 

Downstream Products

• 1289142-75-1 (S,E)-4-(4-chlorophenyl)but-3-en-2-amine 
• 147864-33-3 1-Chloro-4-(2-chloro-1-methylsulfanyl-butyl)-benzene 

Relevant articles and documents

Selecting double bond positions with a single cation-responsive iridium olefin isomerization catalyst

The catalytic transposition of double bonds holds promise as an ideal route to alkenes of value as fragrances, commodity chemicals, and pharmaceuticals; yet, selective access to specific isomers is a challenge, normally requiring independent development of different catalysts for different products. In this work, a single cation-responsive iridium catalyst selectively produces either of two different internal alkene isomers. In the absence of salts, a single positional isomerization of 1-butene derivatives furnishes 2-alkenes with exceptional regioselectivity and stereoselectivity. The same catalyst, in the presence of Na+, mediates two positional isomerizations to produce 3-alkenes. The synthesis of new iridium pincer-crown ether catalysts based on an aza-18-crown-6 ether proved instrumental in achieving cation-controlled selectivity. Experimental and computational studies guided the development of a mechanistic model that explains the observed selectivity for various functionalized 1-butenes, providing insight into strategies for catalyst development based on noncovalent modifications.

Method for synthesizing alkyl olefin through coupling of double-bond carbon-hydrogen bond and saturated carbon-hydrogen bond

The invention discloses a method for synthesizing alkyl olefin through coupling of a double-bond carbon-hydrogen bond and a saturated carbon-hydrogen bond. According to to the method, one-pot reactionis implemented on olefin and sulfoxide in the presence of ferric salt and hydrogen peroxide to generate alkyl olefin; in the method, sulfoxide is simultaneously used as a hydrocarbylation reagent anda solvent of olefin, and a reaction product is alkyl olefin from sulfoxide alkyl coupled with olefin carbon atoms, so that an olefin carbon chain is increased; the reaction conditions are mild, the selectivity is good, the yield is high, and industrial production is facilitated.

Copper catalyzed enantioselective allylic substitution by MeMgX

Methyl Grignard undergoes highly regio (>90/10) and enantioselective (ee 91-96%) copper catalyzed allylic substitution on cinnamyl-type chlorides. CuBr (3%) and 3.3% of a chiral phosphoramidite ligand are sufficient for a complete reaction. The synthesis of a precursor of (+)-Naproxen is described. The reaction can be extended to alkyl substituted allylic chlorides (ee 72%).