18658-65-6

Basic information

• Product Name: Boc-L-Leu-L-Tyr-OMe
• Synonyms: Boc-L-Leu-L-Tyr-OMe
• CAS NO: 18658-65-6
• Molecular Formula: C₂₁H₃₂N₂O₆
• Molecular Weight: 408.48858
• Mol File: 18658-65-6.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Boc-L-Leu-L-Tyr-OMe(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-L-Leu-L-Tyr-OMe(18658-65-6)
• EPA Substance Registry System: Boc-L-Leu-L-Tyr-OMe(18658-65-6)

Safety Data

• Hazardous Substances Data: 18658-65-6(Hazardous Substances Data)

Upstream product

• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 3417-91-2 L-tyrosine methyl ester HCl 
• 1080-06-4 L-Tyr-OMe 
• 24424-99-5 di-tert-butyl dicarbonate 
• 61-90-5 L-leucine 
• 60-18-4 L-tyrosine 
• 16937-99-8 N-Boc-D-Leu 

Downstream Products

• 1447815-65-7 L-isoseryl-L-leucyl-L-tyrosine 
• 1609169-86-9 C₃₂H₅₁N₅O₆ 
• 1575822-60-4 Boc-Leu-DOPA-OMe 
• 1374225-28-1 C₅₅H₉₃N₉O₁₃ 
• 130240-58-3 N-[N-(tert-butoxycarbonyl)-L-leucyl]-L-tyrosine 
• 1367281-42-2 C₁₈H₂₅BrN₂O₅ 
• 15266-78-1 3-(4-hydroxybenzyl)-6-isobutylpiperazine-2,5-dione 
• 26307-85-7 L-leucinyl-L-tyrosine methyl ester hydrochloride 

Relevant articles and documents

Concerning peptide synthesis. Cyclisation with an improved anhydride method

-

Design, synthesis and biological evaluation of novel L-isoserine tripeptide derivatives as aminopeptidase N inhibitors

Aminopeptidase N (APN/CD13) is one of the essential proteins for tumour invasion, angiogenesis and metastasis as it is over-expressed on the surface of different tumour cells. Based on our previous work that L-isoserine dipeptide derivatives were potent APN inhibitors, we designed and synthesized L-isoserine tripeptide derivatives as APN inhibitors. Among these compounds, one compound 16l (IC50=2.51±0.2 M) showed similar inhibitory effect compared with control compound Bestatin (IC50=6.25±0.4 M) and it could be used as novel lead compound for the APN inhibitors development as anticancer agents in the future.

Synthesis, antimicrobial and anthelmintic activity of 2-amino-4-phenylthiazole derivatives of amino acids and peptides

A novel series of 2-amino-4-phenylthiazole derivatives of amino acids and peptides were synthesized by solution phase technique. The synthesized compounds were characterized by FTIR, 1H NMR and mass spectral analysis and evaluated for their antibacterial, antifungal and anthelmintic activities. The compounds exhibited significant antifungal and anthelmintic activities as compared to standard drugs fluconazole and mebendazole, respectively.