18660-81-6 Usage
Description
TETRODOTOXIN CITRATE is a potent marine-derived neurotoxin that reversibly inhibits the inward sodium current through voltage-activated sodium (Nav) channels, blocking nerve and muscle action potentials. It is an indispensable neuroscience tool for pharmacologically dissecting the contribution of the Nav current in excitable neurons and for rationally designing compounds for the treatment of neuropathic pain. This citrate-stabilized form of TTX is designed for improved solubility over pure TTX, which is insoluble in water and most organic solvents. This preparation of TTX citrate consists of TTX that has been dissolved in a citrate solution and then lyophilized.
Uses
Used in Neuroscience Research:
TETRODOTOXIN CITRATE is used as a research tool for elucidating the physical biology of nerve action potentials and studying the role of Nav channels in excitable neurons.
Used in Drug Development:
TETRODOTOXIN CITRATE is used as a pharmacological agent for the rational design of compounds targeting Nav channels, with potential applications in the treatment of neuropathic pain.
Biological Activity
Highly selective, reversible sodium channel blocker; citrate salt of tetrodotoxin.
Check Digit Verification of cas no
The CAS Registry Mumber 18660-81-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,6,6 and 0 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 18660-81:
(7*1)+(6*8)+(5*6)+(4*6)+(3*0)+(2*8)+(1*1)=126
126 % 10 = 6
So 18660-81-6 is a valid CAS Registry Number.
InChI:InChI=1/C11H17N3O8.C6H8O7/c12-8-13-6(17)2-4-9(19,1-15)5-3(16)10(2,14-8)7(18)11(20,21-4)22-5;7-3(8)1-6(13,5(11)12)2-4(9)10/h2-7,15-20H,1H2,(H3,12,13,14);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/t2-,3+,4+,5-,6-,7+,9+,10?,11-;/m1./s1
