186668-70-2

Basic information

• Product Name: DIFLOMOTECAN
• Synonyms: DIFLOMOTECAN
• CAS NO: 186668-70-2
• Molecular Formula: C₂₁H₁₆F₂N₂O₄
• Molecular Weight: 398.363
• Mol File: 186668-70-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: DIFLOMOTECAN(CAS DataBase Reference)
• NIST Chemistry Reference: DIFLOMOTECAN(186668-70-2)
• EPA Substance Registry System: DIFLOMOTECAN(186668-70-2)

Safety Data

• Hazardous Substances Data: 186668-70-2(Hazardous Substances Data)

Usage

Description

Diflomotecan is a synthetic derivative of the quinoline alkaloid camptothecin, which possesses potent anticancer activity by inhibiting the enzyme topoisomerase I. This inhibition results in the accumulation of DNA damage, ultimately leading to cell death in cancer cells. Diflomotecan has demonstrated promise in preclinical and clinical studies for the treatment of various solid tumors, such as lung, breast, and ovarian cancers. Its unique chemical structure and mechanism of action make it a promising candidate for further development as a potential therapy for cancer.

Uses

Used in Oncology:
Diflomotecan is used as an anticancer agent for the treatment of various solid tumors, including lung, breast, and ovarian cancers. Its mechanism of action involves the inhibition of topoisomerase I, leading to the accumulation of DNA damage and inducing cell death in cancer cells.
Used in Pharmaceutical Industry:
Diflomotecan is used as a potential therapy for cancer due to its unique chemical structure and mechanism of action. Its development as a pharmaceutical agent is ongoing, with the aim of improving treatment options for patients with various solid tumors.

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 186668-54-2 (+)-5-ethyl-5-hydroxy-1,3,4,5,8,9-hexahydrooxepino[3,4-c]pyridin-3,9-dione 
• 3863-11-4 3,4-difluoroaniline 
• 186668-51-9 tert-butyl 3-{3-[(benzyloxy)methyl]-2-methoxy-4-pyridinyl}-3-hydroxypentanoate 
• 880767-52-2 3-benzyloxymethyl-4-(2-ethyl[1,3]dioxolan-2-yl)-2-methoxypyridine 
• 186668-52-0 tert-butyl 3-hydroxy-3-[3-(hydroxymethyl)-2-methoxy-4-pyridinyl]pentanoate 
• 186668-50-8 1-{3-[(benzyloxy)methyl]-2-methoxy-4-pyridinyl}-1-propanone 
• 219832-72-1 4(2-ethyl-1,3-dioxan-2-yl)-3-hydroxymethyl-2-methyoxypyridine 
• 186668-53-1 (+)-(5R)-5-Ethyl-5-hydroxy-1-methoxy-5.6-dihydro-9H-8-oxa-2-aza-benzocyclohepten-7-one 
• 209909-03-5 2-chloro-6,7-difluoro-3-quinolinemethanol 
• 880767-51-1 4-(2-ethyl[1,3]dioxolan-2-yl)-2-methoxypyridine-3-carbaldehyde 
• 209909-13-7 2-chloro-6,7-difluoro-3-quinoline-3-carbaldehyde 
• 219832-71-0 4-(2-ethyl[1,3]dioxolan-2-yl)-2-methoxypyridine 
• 87121-53-7 1-(2-chloropyridin-4-yl)propan-1-one 

Relevant articles and documents

Analogues of camptothecin, their use as medicaments and the pharmaceutical compositions containing them

A compound of the formula wherein the substituents are defined as in the specification which compounds are useful in the treatment of cancer.

Comptothecin analogues, preparation methods therefor, use thereof as drugs, and pharmaceutical compositions containing said analogues

The compound of the formula wherein the substituents are defined as in the specification and its non-toxic, pharmaceutically acceptable salts which are useful for the treatment of viral infections, parasitic diseases and the treatment of cancer.