18678-14-3

Basic information

• Product Name: 2-PHENYLTHIENO[3,2-D]PYRIMIDIN-4-OL
• Synonyms: 2-PHENYLTHIENO[3,2-D]PYRIMIDIN-4-OL;2-PHENYL-3H-THIENO[3,2-D]PYRIMIDIN-4-ONE
• CAS NO: 18678-14-3
• Molecular Formula: C₁₂H₈N₂OS
• Molecular Weight: 228.27
• Mol File: 18678-14-3.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-PHENYLTHIENO[3,2-D]PYRIMIDIN-4-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENYLTHIENO[3,2-D]PYRIMIDIN-4-OL(18678-14-3)
• EPA Substance Registry System: 2-PHENYLTHIENO[3,2-D]PYRIMIDIN-4-OL(18678-14-3)

Safety Data

• Hazardous Substances Data: 18678-14-3(Hazardous Substances Data)

Usage

General Description

2-PHENYLTHIENO[3,2-D]PYRIMIDIN-4-OL, also known as PTP-1B inhibitor, is a chemical compound with potential therapeutic applications in treating diabetes and obesity. It acts as an inhibitor of protein tyrosine phosphatase 1B (PTP-1B), an enzyme that plays a key role in insulin signaling and regulation of glucose and lipid metabolism. By inhibiting PTP-1B, this compound has the potential to improve insulin sensitivity and lower blood glucose levels, making it a promising candidate for the development of new anti-diabetic and anti-obesity drugs. Its structure, incorporating a phenyl group and a thieno-pyrimidine ring, provides a unique molecular target for drug development and further research.

Upstream product

• 22288-78-4 Methyl 3-aminothiophene-2-carboxylate 
• 825-60-5 benzimidic acid ethyl ester 
• 108-88-3 toluene 
• 147123-47-5 3-aminothiophene-2-carboxamide 
• 618-32-6 Benzoyl bromide 
• 299199-50-1 N-(quinolin-8-yl)thiophene-2-carboxamide 
• 1670-14-0 benzamidine monohydrochloride 
• 5271-67-0 2-Thiophenecarbonyl chloride 
• 100-42-5 styrene 
• 79128-70-4 methyl 3-benzoylaminothiophene-2-carboxylate 
• 98-88-4 benzoyl chloride 

Downstream Products

• 214417-22-8 4-chloro-2-phenylthieno[3,2-d]pyrimidine 

Relevant articles and documents

Synthesis of 2-aryl quinazolinones: Via iron-catalyzed cross-dehydrogenative coupling (CDC) between N-H and C-H bonds

Herein, we describe the direct synthesis of quinazolinones via cross-dehydrogenative coupling between methyl arenes and anthranilamides. The C-H functionalization of the benzylic sp3 carbon is achieved by di-t-butyl peroxide under air, and the subsequent amination-aerobic oxidation process completes the annulation process. Iron catalyzed the whole reaction process and various kinds of functional groups were tolerated under the reaction conditions, providing 31 examples of 2-aryl quinazolinones using methyl arene derivatives in yields of 57-95percent. The synthetic potential has been demonstrated by the additional synthesis of aryl-containing heterocycles. This journal is

Copper-mediated synthesis of quinazolin-4(3: H)-ones from N-(quinolin-8-yl)benzamide and amidine hydrochlorides

An efficient copper-mediated tandem C(sp2)-H amination to provide quinazolinones from N-(quinolin-8-yl)benzamide and amidine hydrochlorides has been developed. It can afford rather complex products in a single step synthesis from easily availab

Direct metallation of thienopyrimidines using a mixed lithium-cadmium base and antitumor activity of functionalized derivatives

A series of thieno[2,3-d]- and thieno[3,2-d]pyrimidines have been easily synthesized using as key step a deproto-cadmiation-trapping sequence. Some of the compounds thus synthesized were screened for anticancer (cytotoxic) activities, and (S)-2-(6-iodo-2-