186792-85-8

Basic information

• Product Name: 2-[(2-Nitrophenyl)aMino]-3-cyanothiophene
• Synonyms: 2-[(2-Nitrophenyl)aMino]-3-cyanothiophene;2-[(2-Nitrophenyl)aMino]-3-thiophenecarbonitrile
• CAS NO: 186792-85-8
• Molecular Formula: C₁₁H₇N₃O₂S
• Molecular Weight: 245
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 186792-85-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 2-[(2-Nitrophenyl)aMino]-3-cyanothiophene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(2-Nitrophenyl)aMino]-3-cyanothiophene(186792-85-8)
• EPA Substance Registry System: 2-[(2-Nitrophenyl)aMino]-3-cyanothiophene(186792-85-8)

Safety Data

• Hazardous Substances Data: 186792-85-8(Hazardous Substances Data)

Usage

Chemical Properties

Orange Solid

Uses

Intermediate in the preparation of Olanzapine derivatives.

Upstream product

• 635302-32-8 2‐amino‐5‐ethylthiophene‐3‐carbonitrile 
• 1493-27-2 ortho-nitrofluorobenzene 

Downstream Products

• 174756-45-7 2-hydroxymethyl olanzapine 
• 186792-91-6 4-Cyano-5-(2-nitro-phenylamino)-thiophene-2-carboxylic acid methyl ester 
• 186792-89-2 4-Cyano-5-(2-nitro-phenylamino)-thiophene-2-carboxylic acid 
• 186792-87-0 5-Formyl-2-(2-nitro-phenylamino)-thiophene-3-carbonitrile 

Relevant articles and documents

Catalyst-free and selective synthesis of 2-aminothiophenes and 2-amino-4,5-dihydrothiophenes from 4-thiazolidinones in water

2-Aminothiophenes and 2-amino-4,5-dihydrothiophenes were selectively and conveniently synthesized from 4-thiazolidinone derivatives. The meaningful product 10m was efficiently synthesized, which is a commonly-used intermediate for preparing olanzapine. The present method holds many advantages, such as easy operation, high yields, is catalyst-free and uses water as the solvent.