18690-79-4

Basic information

• Product Name: 1,4-Naphthalenedione, 2-methyl-3-phenyl-
• CAS NO: 18690-79-4
• Molecular Formula: C17H12O2
• Molecular Weight: 248.281
• Mol File: 18690-79-4.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: 1,4-Naphthalenedione, 2-methyl-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Naphthalenedione, 2-methyl-3-phenyl-(18690-79-4)
• EPA Substance Registry System: 1,4-Naphthalenedione, 2-methyl-3-phenyl-(18690-79-4)

Safety Data

• Hazardous Substances Data: 18690-79-4(Hazardous Substances Data)

Upstream product

• 673-32-5 1-Phenylprop-1-yne 
• 6383-11-5 benzocyclobutene-1,2-dione 
• 17015-99-5 2-methyl-3-chloronaphthoquinone 
• 98-80-6 phenylboronic acid 
• 423-39-2 1-iodo-2,2,3,3,4,4,5,5,5-nonafluorobutane 
• 58-27-5 menadione 
• 107-18-6 allyl alcohol 
• 94-36-0 dibenzoyl peroxide 
• 591-51-5 phenyllithium 
• 705-60-2 (2-nitroprop-1-enyl)benzene 
• 643-79-8 o-phthalic dicarboxaldehyde 
• 2348-77-8 2-phenyl[1,4]naphthoquinone 
• 75-65-0 tert-butyl alcohol 
• 869476-53-9 3-methyl-4H-spiro[naphthalene-1,2′-[1,3]dioxolan]-4-one 

Relevant articles and documents

An Organotransition-Metal Synthesis of Naphthoquinones

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New, simple and selective synthesis of perfluoroalkylquinones by perfluoroalkyl radicals - Enthalpic and polar effects

Perfluoroalkyl radicals (Rf), generated by iodine abstraction from perfluoroalkyl iodides by phenyl radicals, react selectively with quinone rings in spite of their electrophilic character. In the presence of electron-rich alkenes, Rf/sub

Comprehensive evaluation of antioxidant effects of Japanese Kampo medicines led to identification of Tsudosan formulation as a potent antioxidant agent

Oxidative stress due to the overproduction of reactive oxygen species plays an important role in the pathogenesis of various diseases. In the present study, we comprehensively evaluated the antioxidant activities of 147 oral formulations of Japanese traditional herbal medicines (Kampo medicines), representing the entire panel of oral Kampo medicines listed in the Japanese National Health Insurance Drug List, using in vitro radical scavenging assays, including the 2,2-diphenyl-1-picrylhydrazyl free radical scavenging activity assay, the superoxide anion scavenging activity assay, and the oxygen radical absorption capacity assay. Three of the formulations tested, namely, Tsudosan, Daisaikoto, and Masiningan, showed the most potent in vitro antioxidant activities and were selected for further investigation of their intracellular and in vivo antioxidant effects. The results of the 2′,7′-dichlorodihydrofluorescin diacetate assay demonstrated that all three Kampo medicines significantly inhibited hydrogen peroxide-induced oxidative stress in human hepatocellular liver carcinoma HepG2 cells. In addition, Tsudosan significantly increased the serum biological antioxidant potential values when orally administrated to mice, indicating that it also had in vivo antioxidant activity. The potent antioxidant activity of Tsudosan may be one of the mechanisms closely correlated to its clinical usage against blood stasis.

Iron-Catalyzed Radical Methylation of Activated Alkenes with tert -Butanol as the Methyl Source

A free-radical-initiated methylation/addition/cyclization of N -arylacrylamides and a methylation/addition/elimination of quinines have been developed in which t -BuOH is used as a methyl source. These reactions provide effective and selective methods for the synthesis of various methylated oxindoles and quinones in moderate to good yields.