187099-49-6Relevant articles and documents
Synthesis of indoles from aroyloxycarbamates with alkynes: Via decarboxylation/cyclization
Ma, Nuannuan,Li, Peihe,Wang, Zheng,Dai, Qipu,Hu, Changwen
supporting information, p. 2421 - 2426 (2018/04/12)
An efficient Pd-catalyzed decarboxylation/cyclization of aroyloxycarbamates to realize substituted indoles has been disclosed. Terminal alkynes as the coupling partners lead to site specific 2-substituted indoles through two pathways, while internal alkynes with aroyloxycarbamates can be transformed to 2,3-disubstituted indoles directly. This protocol is further demonstrated by the efficient synthesis of indoles as well as the success of employing inexpensive aryl acids as starting materials to construct C-N bonds by releasing CO2.
Diversely Substituted Quinolines via Rhodium-Catalyzed Alkyne Hydroacylation
Neuhaus, James D.,Morrow, Sarah M.,Brunavs, Michael,Willis, Michael C.
supporting information, p. 1562 - 1565 (2016/05/02)
The Rh-catalyzed hydroacylative union of aldehydes and o-alkynyl anilines leads to 2-aminophenyl enones, and onward to substituted quinolines. The mild reaction conditions employed in this chemistry result in a process that displays broad functional group
Synthesis of 3,4-fused 2-quinolones from an (ortho-aminophenyl)propiolate via sequential cycloaddition/lactam formation
Murayama, Tsukasa,Shibuya, Masatoshi,Yamamoto, Yoshihiko
supporting information, p. 690 - 694 (2015/03/18)
An N-phthalimide-protected (ortho-aminophenyl)propiolate was prepared by the carboxylation of the corresponding silylalkyne precursor with carbon dioxide. The obtained propiolate was further transformed to various 3,4-fused 2-quinolones via cycloadditions and subsequent deprotection/lactam formation.
