187240-78-4

Basic information

• Product Name: dibenzyl 4,10-bis(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,7-dicarboxylate
• Synonyms: dibenzyl 4,10-bis(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,7-dicarboxylate
• CAS NO: 187240-78-4
• Molecular Weight: 668.831
• Mol File: 187240-78-4.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: dibenzyl 4,10-bis(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,7-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: dibenzyl 4,10-bis(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,7-dicarboxylate(187240-78-4)
• EPA Substance Registry System: dibenzyl 4,10-bis(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,7-dicarboxylate(187240-78-4)

Safety Data

• Hazardous Substances Data: 187240-78-4(Hazardous Substances Data)

Upstream product

• 5292-43-3 bromoacetic acid tert-butyl ester 
• 162148-45-0 1,4,7,10-tetraaza-cyclododecane-1,7-dicarboxylic acid dibenzyl ester 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 294-90-6 1,4,7,10-tetraazacyclododecan 
• 501-53-1 benzyl chloroformate 
• 544-00-3 3-methyl-N-(3-methylbutyl)-1-butanamine 

Downstream Products

• 1276543-57-7 4,10-bis-(carbo-tert-butoxymethyl)-14-(4-nitrobenzyl)-1,4,7,10-tetraazabicyclo[5. 5.3]pentadecane 
• 1276543-58-8 4,10-bis-(carbo-tert-butoxymethyl)-14-(4-aminobenzyl)-1,4,7,10-tetraazabicyclo[ 5.5.3]pentadecane 
• 1187176-56-2 2,2'-((4,10-bis(carboxymethyl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)bis(methylene))bis(pyridine 1-oxide) 
• 934755-04-1 1,7-bis(tert-butyloxycarbonylmethylene)-4,10-bis(benzyloxycarbonylmethylene)-1,4,7,10-tetraazacyclododecano 
• 1331910-03-2 1,7-bis-(carbo-tert-butoxymethyl)-4-(4'-aminobenzyl)-1,4,7,10-tetraazacyclododecane 
• 1331910-12-3 1,7-bis-(carbo-tert-butoxymethyl)-4-(4'-aminophenethyl)-1,4,7,10-tetraazacyclododecane 
• 1331910-10-1 1,7-bis-(carbo-tert-butoxymethyl)-4-(4'-nitrophenethyl)-1,4,7,10-tetraazacyclododecane 
• 1331910-01-0 1,7-bis-(carbo-tert-butoxymethyl)-4-(4'-nitrobenzyl)-1,4,7,10-tetraazacyclododecane 
• 1276543-59-9 4,10-bis-(carboxymethyl)-14-(4-aminobenzyl)-1,4,7,10-tetraazabicyclo[5.5.3]pentadecane 
• 162148-48-3 (7-tert-butoxycarbonylmethyl-1,4,7,10-tetraaza-cyclododec-1-yl)-acetic acid tert-butyl ester 

Relevant articles and documents

MACROCYCLIC CHELATES AND USES THEREOF

The present disclosure relates to macrocyclic chelates including a macrocyclic chelating moiety of a metal complex thereof, a bifunctional linker, and a therapeutic or targeting moiety. Also disclosed are methods for preparation of the same, and use thereof.

Magnetofluorescent micelles incorporating DyIII-DOTA as potential bimodal agents for optical and high field magnetic resonance imaging

Dysprosium(iii) was coordinated to four 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) bisamide derivatives functionalized with amphiphilic p-dodecylaniline and p-tetradecylaniline in a differing cis- and trans-orientation. The complexes were assembled into mono-disperse micelles having size distribution maxima ranging from 10 to 15 nm and the magnetic and optical properties of the micelles were examined in detail. The micelles show characteristic Dy(iii) emission with quantum yields reaching 0.8%. The transverse relaxivity r2 per Dy(iii) ion at 500 MHz and 310 K reaches maximum values of ca. 20 s-1 mM-1 which is a large increase when compared to a value of 0.8 s-1 mM-1 observed for DyIII-DTPA. The micelles were stable in water when incubated at 37 °C for 1 week and showed no relaxivity decrease when measured in the presence of 4% (w/v) human serum albumin. The efficient T2 relaxation, especially at strong magnetic fields, is sustained by the high magnetic moment of the dysprosium(iii) ion, the coordination of water molecules and long rotational correlation times.

Detection of NAD(P)H-dependent enzyme activity with dynamic luminescence quenching of terbium complexes

We discovered that positively charged terbium complexes bearing 1,4,7,10-tetraazacyclododecane functionalized with amide ligands are highly sensitive to dynamic luminescence quenching by NAD(P)H. We exploited this phenomenon to establish a general time-re