187283-25-6 Usage
General Description
FMOC-L-PHE(4-GUANIDINO-BOC2)-OH is a chemical compound with the molecular formula C46H51N7O6. It is a derivative of the amino acid phenylalanine, in which the phenyl group is protected by the FMOC (9-fluorenylmethoxycarbonyl) group. Additionally, the guanidino group is protected by the BOC (tert-butoxycarbonyl) group. FMOC-L-PHE(4-GUANIDINO-BOC2)-OH is commonly used in peptide synthesis and as a building block for solid-phase peptide synthesis. It is important in the field of medicinal chemistry and drug development for the creation of peptide-based pharmaceuticals.
Check Digit Verification of cas no
The CAS Registry Mumber 187283-25-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,7,2,8 and 3 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 187283-25:
(8*1)+(7*8)+(6*7)+(5*2)+(4*8)+(3*3)+(2*2)+(1*5)=166
166 % 10 = 6
So 187283-25-6 is a valid CAS Registry Number.
InChI:InChI=1/C35H40N4O8/c1-34(2,3)46-32(43)38-30(39-33(44)47-35(4,5)6)36-22-17-15-21(16-18-22)19-28(29(40)41)37-31(42)45-20-27-25-13-9-7-11-23(25)24-12-8-10-14-26(24)27/h7-18,27-28H,19-20H2,1-6H3,(H,37,42)(H,40,41)(H2,36,38,39,43,44)/t28-/m0/s1
187283-25-6Relevant articles and documents
Photoactivatable peptides based on BMS-197525: A potent antagonist of the human thrombin receptor (PAR-1)
Elliott, John T.,Hoekstra, William J.,Maryanoff, Bruce E.,Prestwich, Glenn D.
, p. 279 - 284 (2007/10/03)
Photoactivatable analogs of the human thrombin receptor (PAR-1) antagonist, N-trans-cinnamoyl-p-fluoroPhe-p-guandinoPhe-Leu-Arg-NH2 (BMS- 197525), were prepared with benzophenone substitutions in the N-terminal, Leu, or Arg position. The analogs retained antagonist activity (with reduced potency); the tritium-labeled isotopomers are potential photoaffinity labels for the receptor. C-Terminal extension of the analogs with ornithine(biotin) did not significantly alter antagonist potency.