18732-50-8

Basic information

• Product Name: Phenol, 2-(5-phenyl-3-isoxazolyl)-
• CAS NO: 18732-50-8
• Molecular Formula: C15H11NO2
• Molecular Weight: 237.258
• Mol File: 18732-50-8.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Phenol, 2-(5-phenyl-3-isoxazolyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 2-(5-phenyl-3-isoxazolyl)-(18732-50-8)
• EPA Substance Registry System: Phenol, 2-(5-phenyl-3-isoxazolyl)-(18732-50-8)

Safety Data

• Hazardous Substances Data: 18732-50-8(Hazardous Substances Data)

Upstream product

• 1469-94-9 1-(2-hydroxyphenyl)-3-phenyl-1,3-propanedione 
• 64-17-5 ethanol 
• 118-93-4 o-hydroxyacetophenone 
• 108-95-2 phenol 
• 620-73-5 phenyl chloroacetate 
• 53074-73-0 2-(2-chloroacetyl)phenol 
• 98-86-2 acetophenone 
• 90-02-8 salicylaldehyde 
• 644-78-0 2-hydroxychalcone 
• 98-88-4 benzoyl chloride 
• 4010-33-7 2-acetylphenyl benzoate 
• 39729-11-8 (2RS,3SR)-2,3-dibromo-1-(2-hydroxy-phenyl)-3-phenyl-propan-1-one 
• 837383-20-7 (E)-1-(2-hydroxyphenyl)-3-phenyl-2-propen-1-one oxime 
• 525-82-6 FLAVONE 

Downstream Products

• 119841-72-4 o-hydroxydibenzoylmethane 
• 525-82-6 FLAVONE 
• 96452-36-7 2,4,6-tri-<5-phenyl-3-(2-phenoxyacetyloxy)isoxazole> acetophenone 
• 96440-25-4 [2-(5-Phenyl-isoxazol-3-yl)-phenoxy]-acetic acid 3-hydroxy-2-{3-oxo-4-[2-(5-phenyl-isoxazol-3-yl)-phenoxy]-butyryl}-5-{2-[2-(5-phenyl-isoxazol-3-yl)-phenoxy]-acetoxy}-phenyl ester 
• 96440-27-6 2,4-di-<5-phenyl-3-(2-phenoxyacetyloxy)isoxazole> acetophenone 
• 96440-23-2 1-(2-Hydroxy-phenyl)-4-[2-(5-phenyl-isoxazol-3-yl)-phenoxy]-butane-1,3-dione 
• 96440-26-5 2-<5-phenyl-3-(2-phenoxyacetyloxy)isoxazole> acetophenone 
• 96440-30-1 <2-(5-phenyl-3-isoxazolyl)-phenoxy> acetic acid 
• 96440-31-2 ethyl <2-(5-phenyl-3-isoxazolyl)-phenoxy> acetate 

Relevant articles and documents

An Intramolecular Wittig Approach toward Heteroarenes: Synthesis of Pyrazoles, Isoxazoles, and Chromenone-oximes

α-Halohydrazones/ketoximes are transformed into trisubstituted pyrazoles/disubstituted isoxazoles by treatment with phosphine, acyl chloride, and a base. Mechanistic investigations revealed the in situ formation of azo/nitroso olefin intermediates which underwent a tandem phospha-Michael/N- or O-acylation/intramolecular Wittig reaction to afford the heteroarenes in moderate to good yields. Further, proper functionalization of α-haloketoximes and a change of conditions allowed the chemoselective synthesis of chromenone-oximes as well as rearranged isoxazoles, thereby realizing a diversity-oriented synthesis.

Synthesis and in-vivo hypolipidemic activity of some novel substituted phenyl isoxazol phenoxy acetic acid derivatives

The present study was undertaken to evaluate in-vivo hypolipidemic activity of a novel series of 2-methyl-2-(substituted phenyl isoxazol)phenoxyacetic acid derivatives by triton induced hyperlipidemia in rats. The newly synthesized compounds 5a, 5d and 5g showed significant decrease in the serum TCH, TG, LDL and VLDL along with an increase in serum HDL levels as compared to standard drug Fenofibrate. The treated groups also showed significant decrease in the atherogenic index and increase in % protective activity compared to control group.

Benzo-γ-pyrones. Part XVI. Synthesis and Characterisation of 3-(2-Hydroxyphenyl)-5-phenylisoxazole

Synthesis of 3-(2-hydroxyphenyl)-5-phenylisoxazole (2) by oxidation of (E)-1-(2-hydroxyphenyl)-3-phenyl-2-propen-1-one oxime (3) is described.Spectroscopic evidences (UV, IR, MS, 1H and 13C NMR) for the structure 2 are given.Key words: 3-(2-hydroxyphenyl)