187543-87-9

Basic information

• Product Name: 2,3-DIFLUORO-6-METHOXYBENZALDEHYDE
• Synonyms: 5,6-Difluoro-o-anisaldehyde;2,3-Difluoro-6-methoxybezaldehyde;3,4-Difluoro-2-formylanisole, 5,6-Difluoro-o-anisaldehyde;2,3-DIFLUORO-6-METHOXYBENZALDEHYDE;2,3-Difluoro-6-methoxybenzaldehyde 98%;2,3-Difluoro-6-methoxybenzaldehyde98%;2,3-DIFLUORO-6-METHOXY-BENZALDEHYD, 98+%
• CAS NO: 187543-87-9
• Molecular Formula: C₈H₆F₂O₂
• Molecular Weight: 172.13
• Product Categories: Fluorine series;Aromatic Aldehydes & Derivatives (substituted);Benzaldehyde
• Mol File: 187543-87-9.mol
• Article Data: 11

Chemical Properties

• Melting Point: 55-57
• Boiling Point: 233°Cat760mmHg
• Flash Point: 92.1°C
• Appearance: /
• Density: 1.289g/cm³
• Vapor Pressure: 0.0571mmHg at 25°C
• Refractive Index: 1.506
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive: Air Sensitive
• CAS DataBase Reference: 2,3-DIFLUORO-6-METHOXYBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIFLUORO-6-METHOXYBENZALDEHYDE(187543-87-9)
• EPA Substance Registry System: 2,3-DIFLUORO-6-METHOXYBENZALDEHYDE(187543-87-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37
• Hazardous Substances Data: 187543-87-9(Hazardous Substances Data)

Usage

General Description

2,3-Difluoro-6-methoxybenzaldehyde is a chemical compound with the molecular formula C9H7F2O2. It is a benzaldehyde derivative that contains two fluorine atoms and a methoxy group attached to the benzene ring. 2,3-DIFLUORO-6-METHOXYBENZALDEHYDE is commonly used in organic synthesis and medicinal chemistry as a building block for the production of various pharmaceuticals and agrochemicals. It is known for its strong aromatic odor and is typically handled and stored in a cool, dry place away from sources of heat and ignition. 2,3-Difluoro-6-methoxybenzaldehyde has the potential to be a valuable tool for researchers and chemists working in drug discovery and development.

InChI:InChI=1/C8H6F2O2/c1-12-7-3-2-6(9)8(10)5(7)4-11/h2-4H,1H3

Upstream product

• 758-16-7 N,N-dimethylthioformamide 
• 115144-40-6 1,2-difluoro-4-methoxy-benzene 
• 68-12-2 N,N-dimethyl-formamide 
• 2713-33-9 3,4-difluorophenol 

Downstream Products

• 741714-88-5 (2,4-Dichloro-pyrimidin-5-yl)-(2,3-difluoro-6-methoxy-phenyl)-methanol 
• 1056265-13-4 7-fluoro-1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-4-(methyloxy)-1H-indazole 
• 1056262-54-4 7-fluoro-1-(3-fluoro-4-hydroxyphenyl)-1H-indazol-4-ol 
• 935283-04-8 3-[2-fluoro-5-(2,3-difluoro-6-methoxybenzyloxy)-4-methoxyphenyl]-2,4-dioxo-1,2,3,4-tetrahydrothieno[3,4- d]pyrimidine-5-carboxylic acid 
• 1321816-57-2 3-[2-fluoro-5-(2,3-difluoro-6-methoxybenzyloxy)-4-methoxyphenyl]-2,4-dioxo-1,2,3,4-tetrahydrothieno[3,4- d]pyrimidine-5-carboxylic acid (2-hydroxyethyl)trimethylammonium 
• 935287-59-5 2-fluoro-5-[(2,3-difluoro-6-methoxyphenyl)methoxy]-4-methoxyaniline 
• 1073435-71-8 1,2-difluoro-3-[(4-fluoro-2-methoxy-5-nitrophenoxy)methyl]-4-methoxybenzene 
• 1073435-69-4 1,2-difluoro-3-[(4-fluoro-2-methoxyphenoxy)methyl]-4-methoxybenzene 
• 1073435-67-2 3-(chloromethyl)-1,2-difluoro-4-methoxybenzene 
• 773871-99-1 2,3-difluoro-6-methoxybenzyl alcohol 
• 886501-77-5 (2,3-difluoro-6-methoxyphenyl)methanamine 

Relevant articles and documents

A practical method for stabilizing lithiated halogenated aromatic compounds

An exothermic decomposition was observed during a metalation/acylation of 3,4-difluoroanisole (5), resulting in a significant thermal hazard. The lithiated anion 6 was found to decompose exothermically at temperatures above -47°C showing an adiabatic temp

2,3-difluoro-6-methoxybenzene process for the preparation of formaldehyde (by machine translation)

The invention discloses a 2,3-difluoro-6-methoxybenzene process for the preparation of formaldehyde, the compound 3,4-difluoroanisole steams newly methyl tetrahydrofuran is added in, weighing anhydrous magnesium chloride, stirring the mixture at room temp

METHODS FOR STABILIZING LITHIATED HALOGEN-SUBSTITUTED AROMATIC COMPOUNDS

The present invention provides novel methods for stabilizing lithiated halogen-substituted aromatic compounds. In particular, the method is useful for the preparation of 2-methoxy-5, 6-difluorobenzaldehyde, an important intermediate for the preparation of