187722-67-4Relevant articles and documents
TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy
Nozal, Vanesa,Martínez-González, Loreto,Gomez-Almeria, Marta,Gonzalo-Consuegra, Claudia,Santana, Paula,Chaikuad, Apirat,Pérez-Cuevas, Eva,Knapp, Stefan,Lietha, Daniel,Ramírez, David,Petralla, Sabrina,Monti, Barbara,Gil, Carmen,Martín-Requero, Angeles,Palomo, Valle,de Lago, Eva,Martinez, Ana
, p. 1585 - 1607 (2022/01/20)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease without any effective treatment. Protein TDP-43 is a pathological hallmark of ALS in both sporadic and familiar patients. Post-translational modifications of TDP-43 promote its aggre
Heterocyclic ring-fused pyrimidine derivatives
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, (2016/01/12)
The present invention relates to heterocyclic ring-fused pyrimidine derivatives of formula (I) or stereoisomers, pharmaceutically acceptable salts or prodrugs thereof, wherein Z and Y are as defined in the specification. Compounds of formula (I) are useful in the treatment of hyperproliferative diseases, such as cancers and acnes, in mammals: