1879-52-3

Basic information

• Product Name: Benzene, 1-chloro-4-(1-propenyl)-, (Z)-
• Synonyms: (Z)-1-(4-chlorophenyl)-1-propene;Z-1-(p-chlor-phenyl)-propen;(Z)-1-(4-chlorophenyl)propene;(Z)-1-(p-chlorophenyl)-1-propene;1-Chloro-4-((Z)-propenyl)-benzene;cis-4-chloro-β-methylstyrene;(Z)-1-chloro-4-propenylbenzene
• CAS NO: 1879-52-3
• Molecular Formula: C9H9Cl
• Molecular Weight: 152.623
• Mol File: 1879-52-3.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 72 °C (8 mmHg)
• CAS DataBase Reference: Benzene, 1-chloro-4-(1-propenyl)-, (Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-chloro-4-(1-propenyl)-, (Z)-(1879-52-3)
• EPA Substance Registry System: Benzene, 1-chloro-4-(1-propenyl)-, (Z)-(1879-52-3)

Safety Data

• Hazardous Substances Data: 1879-52-3(Hazardous Substances Data)

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 100-52-7 benzaldehyde 
• 1754-88-7 ethylenetriphenylphosphorane 
• 17847-85-7 triethyl(ethylidene)phosphorane 
• 1745-18-2 1-allyl-4-chlorobenzene 
• 1202-60-4 3-(4-chlorophenyl)-3-methyl-2-acrylic acid 
• 2809-65-6 4-chloro-1-propynylbenzene 
• 1202-60-4 -2-methyl-3-(4-chlorophenyl)prop-2-enoic acid 
• 873-73-4 4-n-chlorophenylacetylene 
• 599-70-2 ethyl phenyl sulfone 
• 873-76-7 para-Chlorobenzyl alcohol 
• 896-33-3 ethyltriphenylphosphonium chloride 
• 1135820-79-9 C₂₁H₂₂OP⁽¹⁺⁾*I^(1-) 
• 1135821-12-3 ethyl-(2-methoxy-phenyl)-diphenyl-phosphonium; iodide 

Downstream Products

• 135682-94-9 cis-4-chloro-β-methylstyrene oxide 
• 1879-53-4 E-1-(4-chlorophenyl)-1-propene 
• 1404433-42-6 (1R,2R,3S)-2,6-dimethylphenyl 2-(4-chlorophenyl)-3-methylcyclopropanecarboxylate 
• 1886-50-6 (+/-)-cis-1-(4-Chlorphenyl)-2-methyl-ethylenoxid 
• 50337-50-3 2-(4'-chlorophenyl)-3-methyloxirane 

Relevant articles and documents

Cis Selectivity of "Salt-Free" Wittig Reactions: A "Leeward Approach" of the Aldehyde at the Origin?

-

Cobalt-Catalyzed Z to e Isomerization of Alkenes: An Approach to (E)-β-Substituted Styrenes

An efficient cobalt-catalyzed Z to E isomerization of β-substituted styrenes using the amido-diphosphine ligand was developed, delivering the (E)-isomers with good functional tolerance and high stereoselectivity. The reaction could be scaled up to gram-scale with a catalyst loading of 0.1 mol %, using a mixture of (Z)- and (E)-alkene as the starting material. Preliminary mechanistic studies indicated that cobalt(I)-hydride and a benzylic-cobalt species were probably involved in the reaction, as supported by experiments and DFT calculations.

Engineering P450 Peroxygenase to Catalyze Highly Enantioselective Epoxidation of cis-β-Methylstyrenes

P450 119 peroxygenase and its site-directed mutants are discovered to catalyze the enantioselective epoxidation of methyl-substituted styrenes. Two new site-directed P450 119 mutants, namely T213Y and T213M, which were designed to improve the enantioselectivity and activity for the epoxidation of styrene and its methyl substituted derivatives, were studied. The T213M mutant is found to be the first engineered P450 peroxygenase that shows highly enantioselective epoxidation of cis-β-methylstyrenes, with up to 91 % ee. Molecular modeling studies provide insights into the different catalytic activity of the T213M mutant and the T213Y mutant in the epoxidation of cis-β-methylstyrene. The results of the calculations also contribute to a better understanding of the substrate specificity and configuration control for the regio- and stereoselective peroxygenation catalyzed by the T213M mutant.

Nickel-Catalyzed Allylic C(sp2)–H Activation: Stereoselective Allyl Isomerization and Regiospecific Allyl Arylation of Allylarenes

Stereoselective allyl isomerization and regiospecific allyl arylation reactions of allylarenes with a catalytic system comprising nickel(II) with an aryl Grignard reagent were studied. Both reactions are triggered by allylic internal C(sp2)–H activation by in-situ-formed Ni0, which is inserted into the C–H bond at the 2-position of the allyl moiety without a directing group. The isomerization of allylarene to 1-propenylarene favors the E isomer and proceeds with quantitative conversion. The arylation takes place through oxidative cross-coupling of allylarenes with excess Grignard reagent. It occurs regiospecifically at the position of C(sp2)–H activation and represents a new method for the synthesis of 1,1-disubstituted olefins. The results of deuterium labeling experiments reveal an alkenyl/alkyl mechanism involving allylic internal C(sp2)–H activation and multiple intermolecular 1,2-, 1,3-, and 2,3-hydride shifts. These methods represent new approaches to the functionalization of olefins, and the mechanistic investigations could be helpful for the discovery and design of new strategies for olefin functionalization.