1882873-21-3 Usage
Description
1-2-chloro-4-[(6-cyano-7-methoxy-quinolin-4-yl)oxy]phenyl-3-cyclopropylurea is a chemical compound with a complex molecular structure. It is characterized by the presence of a 2-chloro-4-phenyl group, a 6-cyano-7-methoxy-quinolin-4-yloxy group, and a cyclopropylurea moiety. 1-2-chloro-4-[(6-cyano-7-methoxy-quinolin-4-yl)oxy]phenyl-3-cyclopropylurea is an impurity of Lenvatinib (L329400), which is an orally active inhibitor of multiple receptor tyrosine kinases, including VEGF, FGF, and SCF receptors.
Uses
Used in Pharmaceutical Industry:
1-2-chloro-4-[(6-cyano-7-methoxy-quinolin-4-yl)oxy]phenyl-3-cyclopropylurea is used as an impurity in the development and production of Lenvatinib (L329400) for its application as an orally active inhibitor of multiple receptor tyrosine kinases. The compound plays a role in the overall effectiveness and safety profile of Lenvatinib, which is used in the treatment of various cancers by targeting the specific receptors involved in cancer cell growth and angiogenesis.
Used in Research and Development:
In the field of research and development, 1-2-chloro-4-[(6-cyano-7-methoxy-quinolin-4-yl)oxy]phenyl-3-cyclopropylurea serves as a valuable compound for studying the structure-activity relationships of Lenvatinib and other receptor tyrosine kinase inhibitors. Understanding the properties and interactions of this impurity can help researchers optimize the design and synthesis of more effective and safer cancer therapeutics.
Used in Quality Control and Regulatory Compliance:
1-2-chloro-4-[(6-cyano-7-methoxy-quinolin-4-yl)oxy]phenyl-3-cyclopropylurea is also used in the quality control and regulatory compliance processes for Lenvatinib. Ensuring the purity and consistency of pharmaceutical products is crucial for their safety and efficacy. By monitoring and controlling the levels of this impurity, manufacturers can maintain the quality of Lenvatinib and comply with regulatory standards.
Check Digit Verification of cas no
The CAS Registry Mumber 1882873-21-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,8,8,2,8,7 and 3 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1882873-21:
(9*1)+(8*8)+(7*8)+(6*2)+(5*8)+(4*7)+(3*3)+(2*2)+(1*1)=223
223 % 10 = 3
So 1882873-21-3 is a valid CAS Registry Number.
1882873-21-3Relevant articles and documents
Preparation method of lenvatinib mesylate
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Paragraph 0016-0019, (2021/01/15)
The invention relates to a preparation method of lenvatinib mesylate, in particular to a method for efficiently synthesizing lenvatinib mesylate by taking 4-chloro-6-cyano-7-methoxy quinoline and 2-chloro-4-hydroxy aniline formic acid cyclopropanamide as raw materials through two steps of substitution reaction and hydrolysis reaction. The preparation method of lenvatinib mesylate provided by the invention is a preparation method which is short in steps, high in yield, low in cost, less in three wastes, good in product purity and suitable for industrialization.
