18830-44-9

Basic information

• Product Name: METHYL 3,3,3-TRIFLUOROPROPIONATE
• Synonyms: METHYL 3,3,3-TRIFLUOROPROPIONATE;Methyl 3,3,3-trifluoropropanoate;Propanoic acid, 3,3,3-trifluoro-, Methyl ester;Methyl 3,3,3-trifluoropropionate, 98.5%
• CAS NO: 18830-44-9
• Molecular Formula: C₄H₅F₃O₂
• Molecular Weight: 142.08
• EINECS: 1592732-453-0
• Product Categories: Small molecule
• Mol File: 18830-44-9.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 95-96°C
• Flash Point: -1℃
• Appearance: /
• Density: 1.241
• Vapor Pressure: 1150mmHg at 25°C
• Refractive Index: 1.3318
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: METHYL 3,3,3-TRIFLUOROPROPIONATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 3,3,3-TRIFLUOROPROPIONATE(18830-44-9)
• EPA Substance Registry System: METHYL 3,3,3-TRIFLUOROPROPIONATE(18830-44-9)

Safety Data

• Hazard Codes: F,Xi
• Statements: 10-36/37/38
• Safety Statements: 16-36/37/39-26
• RIDADR: 3272
• HazardClass: IRRITANT, FLAMMABLE
• PackingGroup: II
• Hazardous Substances Data: 18830-44-9(Hazardous Substances Data)

Usage

General Description

Methyl 3,3,3-trifluoropropionate is a chemical compound with the molecular formula C4H5F3O2. It is a colorless liquid with a fruity odor, commonly used as an intermediate in the production of pharmaceuticals, agrochemicals, and other organic compounds. Methyl 3,3,3-trifluoropropionate is also utilized in the manufacturing of fluorinated products, such as pharmaceuticals and agrochemicals, due to its high reactivity and stability. Methyl 3,3,3-trifluoropropionate is considered to be relatively safe, with low acute toxicity, but should still be handled with caution and in accordance with proper safety protocols.

InChI:InChI=1/C3H3F5O/c4-2(5)9-1-3(6,7)8/h2H,1H2

Upstream product

• 382-26-3 1,1,1,3,3-pentafluoro-3-methoxy-2-trifluoromethylpropane 
• 154027-19-7 2-methoxy-5,5-dimethyl-2-(2,2,2-trifluoroethoxy)-Δ³-1,3,4-oxadiazoline 
• 116586-94-8 3,3,3-trifluoropropanal dimethyl acetal 
• 67-56-1 methanol 
• 41463-83-6 3,3,3-trifluoropropanoyl chloride 
• 20618-02-4 methyl 3,3,3-trichloropropanoate 
• 2516-99-6 3,3,3-Trifluoropropionic acid 
• 61153-03-5 trimethylsilyl diazomethane 
• 328-42-7 Oxalacetic acid 
• 360-54-3 methyl 2-(trifluoromethyl)-3,3,3-trifluoropropionate 

Downstream Products

• 93247-30-4 2-(4-tert-Butyl-1-methoxy-cyclohexyl)-3,3,3-trifluoro-propionic acid methyl ester 
• 93855-01-7 3,3,3-Trifluoro-2-(methoxy-phenyl-methyl)-propionic acid methyl ester 
• 406-05-3 methyl β,β-difluoroacrylate 
• 2516-99-6 3,3,3-Trifluoropropionic acid 
• 934171-99-0 3,3,3-trifluoropropanehydrazide 
• 173558-71-9 2-diazo-3,3,3-trifluoropropionic acid methyl ester 

Relevant articles and documents

Novel preparation method of 3, 3, 3-trifluoropropionic acid

The invention discloses a novel preparation method of 3, 3, 3-trifluoropropionic acid, and relates to the field of medical pesticides. 1, 1-dichloroethylene is used as a raw material to be subjected to an addition reaction with chloroformate or ester under the catalysis of iron powder to obtain trichloropropionate or salt thereof, the trichloropropionate or salt thereof is smoothly subjected to afluorination reaction under proper conditions to efficiently obtain trifluoropropionate or fluorine trifluoropropionate, and the trifluoropropionate or fluorine trifluoropropionate is hydrolyzed to obtain 3, 3, 3-trifluoropropionic acid. In conclusion, the method for preparing trifluoropropionic acid has the advantages of cheap and easily available initial raw materials, simple reaction operation,mild reaction conditions, few steps and high conversion rate, and the conversion rate of the raw material 1, 1-dichloroethylene exceeds 78%.

Synthetic method of methyl 3,3,3-trifluoropropionate

The invention discloses a preparation method of methyl 3,3,3-trifluoropropionate. The method is characterized in that methyl 3,3,3-trifluoropropionate is prepared from 3,3,3-trifluoropropionic acid and anhydrous methanol through carrying out a one step reaction at 60-100DEG C under magnetic stirring for 2-12h with a slightly soluble compound as a catalyst, The method has the characteristics of few steps, simple operation, environmental protection and high yield, and is suitable for industrial production.

Bis-exo-2-norbornylboron triflate for stereospecific enolization of 3,3,3-trifluoropropionates

The first boron-mediated enolization - aldolization of 3,3,3- trifluoropropionates has been reported. The preparation and application of bis-exo-bicyclo[2.2.1]heptan-2-ylboron triflate as a superior reagent for diastereospecific enolization has also been described.