18841-73-1

Basic information

• Product Name: (17beta)-9,17-dihydroxyandrost-4-en-3-one
• CAS NO: 18841-73-1
• Molecular Formula: C₁₉H₂₈O₃
• Molecular Weight: 304.4238
• Mol File: 18841-73-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 471.2°C at 760 mmHg
• Flash Point: 252.9°C
• Density: 1.19g/cm³
• Vapor Pressure: 7.36E-11mmHg at 25°C
• Refractive Index: 1.58
• CAS DataBase Reference: (17beta)-9,17-dihydroxyandrost-4-en-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: (17beta)-9,17-dihydroxyandrost-4-en-3-one(18841-73-1)
• EPA Substance Registry System: (17beta)-9,17-dihydroxyandrost-4-en-3-one(18841-73-1)

Safety Data

• Hazardous Substances Data: 18841-73-1(Hazardous Substances Data)

Usage

Description

(17beta)-9,17-dihydroxyandrost-4-en-3-one, also known as 9,17-dihydroxyandrost-4-ene-3-one or 9,17-dihydroxyandrost-4-en-3-one, is a steroid hormone and an intermediate in the biosynthesis of androgens and estrogens. It is a derivative of androstenedione, which is involved in the production of testosterone and estrone. (17beta)-9,17-dihydroxyandrost-4-en-3-one plays a crucial role in the endocrine system and is a precursor to several important hormones in the human body. It is also used as a substrate in various biochemical studies and research related to hormonal regulation and metabolism.

Uses

Used in Pharmaceutical Industry:
(17beta)-9,17-dihydroxyandrost-4-en-3-one is used as an intermediate in the biosynthesis of androgens and estrogens for the development of pharmaceutical products targeting hormonal imbalances and related health conditions.
Used in Biochemical Research:
(17beta)-9,17-dihydroxyandrost-4-en-3-one is used as a substrate in biochemical studies and research focused on hormonal regulation and metabolism, aiding in the understanding of endocrine system functions and the development of treatments for related disorders.

Upstream product

• 57-88-5 cholesterol 
• 58-22-0 testosterone 

Relevant articles and documents

Steroid 9α-hydroxylation during testosterone degradation by resting Rhodococcus equi cells

The conversion pathway of testosterone to androst-4-ene-3,17-dione and 9α-hydroxy androstane metabolites, 9α-hydroxyandrost-4-ene-3,17- dione and 9α,17β-dihydroxyandrost-4-en-3-one was proposed for the ring degradation in steroids by a minimal liquid medium (NMMP)-dispersed Rhodococcus equi ATCC 14887. The microorganism produced 9α-hydroxy androstane metabolites from testosterone at high conversion ratio without the addition of ring degradation inhibitory agents. Several NMMP-based media showed the similar effect on the microbial transformation, in which the respective molar yields of 9α-hydroxyandrost-4-ene-3,17-dione and 9α,17β-dihydroxyandrost-4-en-3-one were approx. 3 to 47% and approx. 3 to 11%, respectively, whereas nutrient broth, a rich medium, basically showed no accumulation. On the basis of this evidence, magnesium sulfate and casamino acids among the components of NMMP were found to compromise the determinant for the production of the 9α-hydroxy androstane metabolites without appreciable decomposition of the steroid ring system.