188440-24-6Relevant articles and documents
Discovery of novel quinoline sulphonamide derivatives as potent, selective and orally active RORγ inverse agonists
Amaudrut, Jér?me,Argiriadi, Maria A.,Barth, Martine,Breinlinger, Eric C.,Bressac, Didier,Broqua, Pierre,Calderwood, David J.,Chatar, Mohamed,Cusack, Kevin P.,Gauld, Stephen B.,Jacquet, Sébastien,Kamath, Rajesh V.,Kort, Michael E.,Lepais, Valérie,Luccarini, Jean-Michel,Masson, Philippe,Montalbetti, Christian,Mounier, Laurent,Potin, Dominique,Poupardin, Olivia,Rouaud, Sylvie,Spitzer, Luc,Wallace, Craig D.
, p. 1799 - 1806 (2019)
A high-throughput screen against Inventiva's compound library using a Gal4/RORγ-LBD luciferase reporter gene assay led to the discovery of a new series of quinoline sulphonamides as RORγ inhibitors, eventually giving rise to a lead compound having an inte
