188493-61-0

Basic information

• Product Name: 4-methyl-N′-(3,4,5-trimethoxybenzylidene)-benzenesulfonohydrazide
• Synonyms: 4-methyl-N′-(3,4,5-trimethoxybenzylidene)-benzenesulfonohydrazide
• CAS NO: 188493-61-0
• Molecular Weight: 364.422
• Mol File: 188493-61-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4-methyl-N′-(3,4,5-trimethoxybenzylidene)-benzenesulfonohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-N′-(3,4,5-trimethoxybenzylidene)-benzenesulfonohydrazide(188493-61-0)
• EPA Substance Registry System: 4-methyl-N′-(3,4,5-trimethoxybenzylidene)-benzenesulfonohydrazide(188493-61-0)

Safety Data

• Hazardous Substances Data: 188493-61-0(Hazardous Substances Data)

Upstream product

• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 

Relevant articles and documents

A simple method for the synthesis of substituted benzylic ketones: Homologation of aldehydes via the in situ generation of aryldiazomethanes from aromatic aldehydes

A general method for the homologation of aldehydes to benzylic ketones has been developed. Aryldiazomethanes were generated in situ in the presence of an aldehyde by simply heating the tosylhydrazones of aromatic aldehydes in the presence of a stoichiometric amount of base in polar protic solvents. The resulting polar protic solvent promoted homologation afforded benzylic ketones in moderate to excellent yields with a variety of aldehydes. Isolation of the tosylhydrazones was not necessary; they could be prepared in ethanol and carried through the sequence without isolation. This methodology allows easy access to a wide variety of substituted aryldiazomethanes that would be difficult, or even impossible, to prepare via conventional methods and circumvents the toxicity and stability problems associated with the isolation and/or handling solutions of aryldiazomethanes.

One-Pot Reaction between N-Tosylhydrazones and 2-Nitrobenzyl Bromide: Route to NH-Free C2-Arylindoles

A one-pot Barluenga coupling between N-tosylhydrazones and nitro-benzyl bromide, followed by deoxygenation of ortho-nitrostyrenes, and subsequent cyclization has been developed, providing a new way to synthesize various C2-arylindoles. This method exhibits a good substrate scope and functional group tolerance, and it allows an access to NH-free indoles, which can present a potential utility in medicinal chemistry applications.

Synthesis and biological evaluation of 2,3-diarylthiophene analogues of combretastatin A-4

A series of novel 2,3-diarylthiophene analogues of combretastatin A-4 (CA-4) were designed with a rigid thiophene moiety to retain the cis-olefin configuration of CA-4 and were subsequently synthesised. All of the target compounds were evaluated for their