1885-87-6

Basic information

• Product Name: 1-Piperidinamine, N-(phenylmethylene)-
• CAS NO: 1885-87-6
• Molecular Formula: C12H16N2
• Molecular Weight: 188.272
• Mol File: 1885-87-6.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 1-Piperidinamine, N-(phenylmethylene)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinamine, N-(phenylmethylene)-(1885-87-6)
• EPA Substance Registry System: 1-Piperidinamine, N-(phenylmethylene)-(1885-87-6)

Safety Data

• Hazardous Substances Data: 1885-87-6(Hazardous Substances Data)

Usage

Structure

A derivative of piperidinamine with a phenylmethylene group attached to the nitrogen atom

Usage

Intermediate in the synthesis of various pharmaceuticals and organic compounds

Applications

Building block in the production of antihistamines, antipsychotic medications, and other pharmaceuticals

Biological and pharmacological activities

Possesses a variety of potential activities, utilized in medicinal chemistry research and drug development

Additional uses

Catalyst in organic reactions and reagent in chemical synthesis

Upstream product

• 2213-43-6 1-Aminopiperidine 
• 100-52-7 benzaldehyde 
• 54237-25-1 1-methyl-3,5-bis(phenylmethylidene)piperidin-4-one hydrochloride 
• 110-89-4 piperidine 

Downstream Products

• 117834-66-9 benzaldehyde N¹-(4-nitrophenylthio)-N²,N²-pentamethylenehydrazonium chloride 
• 112080-79-2 5-Methylsulfonamido-3-methylsulfonyl-5-phenyl-1-piperidino-imidazolidin-2,4-dion 
• 112080-80-5 5-Phenyl-1-piperidino-5-(p-tolylsulfonamido)-3-(p-tolylsulfonyl)-imidazolidin-2,4-dion 
• 100010-82-0 6-Phenyl-5-piperidino-1,3-di-(p-tolylsulfonyl)hexahydro-1,3,5-triazin-2,4-dion 
• 117834-82-9 N,N-pentamethylenebenzothiohydrazide 
• 256934-12-0 N-piperidino-2-phenyl-3-methoxy-2,5-dihydropyrrole 
• 341979-50-8 1-N-piperidinyl-amino-1-phenyl-2-methoxybuta-2,3-diene 
• 1247822-08-7 3-(4-bromophenyl)-2,2-difluoro-3-hydroxy-1-phenylpropan-1-one 
• 114701-62-1 ethyl 2,2-difluoro-3-oxo-3-phenylpropanoate 
• 1247822-13-4 2,2-difluoro-3-hydroxy-3-(4-nitrophenyl)-1-phenylpropan-1-one 
• 395-01-7 2,2-difluoro-1-phenylethanone 

Relevant articles and documents

Visible Light-Induced [3+2] Cyclization Reactions of Hydrazones with Hypervalent Iodine Diazo Reagents for the Synthesis of 1-Amino-1,2,3-Triazoles

In this study, visible-light-induced [3+2] cyclization reactions of hydrazones with hypervalent iodine diazo reagents as diazomethyl radical precursors are reported. Mild reaction conditions, a broad substrate scope, and excellent functional group compatibility were observed. Furthermore, the synthetic utility was demonstrated by gram-scale synthesis and elaboration to several value-added products. This protocol broadens the scope of diazo chemistry, and is applicable to the late-stage functionalization of natural products. (Figure presented.).

Visible-light-enabled C(sp2)-H difluoroalkylation of aldehyde-derived hydrazones under metal-free conditions

A Eosin Y-catalyzed C(sp2)-H difluoromethylation of aldehyde-derived hydrazones between difluoroalkyl bromides and aldehyde-derived hydrazones is reported. This reaction has a wide range of substrates and occurs under metal-free condition. A me

Continuous Flow α-Arylation of N,N-Dialkylhydrazones under Visible-Light Photoredox Catalysis

The first direct α-arylation of aldehyde-derived N,N-dialkylhydrazones with electron deficient aryl and heteroaryl cyanides under visible-light photoredox catalysis has been developed. Structurally complex α,α′-diaryl-N,N-cycloalkylhydrazones were obtaine