188548-07-4

Basic information

• Product Name: 5-Oxo-2-phenethyl-pyrrolidine-2-carboxylic acid ethyl ester
• Synonyms: 5-Oxo-2-phenethyl-pyrrolidine-2-carboxylic acid ethyl ester
• CAS NO: 188548-07-4
• Molecular Weight: 261.321
• Mol File: 188548-07-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-Oxo-2-phenethyl-pyrrolidine-2-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Oxo-2-phenethyl-pyrrolidine-2-carboxylic acid ethyl ester(188548-07-4)
• EPA Substance Registry System: 5-Oxo-2-phenethyl-pyrrolidine-2-carboxylic acid ethyl ester(188548-07-4)

Safety Data

• Hazardous Substances Data: 188548-07-4(Hazardous Substances Data)

Upstream product

• 17376-04-4 2-phenethyl iodide 
• 7149-65-7 ethyl (S)-pyroglutamate 
• 170943-41-6 2-(Benzhydrylidene-amino)-4-phenyl-butyric acid ethyl ester 
• 180609-02-3 2-(Benzhydrylidene-amino)-2-phenethyl-pentanedioic acid diethyl ester 

Downstream Products

• 188548-20-1 ethyl N-(tert-butoxycarbonyl)-2-(2-phenylethyl)-4-methylenepyroglutamate 
• 180609-04-5 5-Oxo-2-phenethyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester 

Relevant articles and documents

Synthesis of 2-substituted 4methyleneglutamic acids and their cyclopropyl analogues

The alkylation of the dianion 10 derived from ethyl 4-methylenepyroglutamate (9) allows the synthesis of 2-substituted 4-methylenepyroglutamates 12, after final W-Boc protection. They can also be prepared by alkylation at the 2-position of dianion 14 deri