188578-52-1Relevant articles and documents
Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents
-
, (2008/06/13)
This invention relates to compounds of the formula STR1 wherein R1 and R6 are each independently C1 -C6 alkyl; R2, R3 and R4 are each independently hydrogen or C1 -C6 alkyl; R is hydrogen or --C(O)--(CH2)m --Q wherein Q is hydrogen or --COOH and m is an integer 1, 2, 3 or 4; Z is a thio, oxy or methylene group; A is a C1 -C4 alkylene group; R5 and R7 are each independently a C1 -C6 alkyl or --(CH2)n --(Ar) wherein n is an integer 0, 1, 2 or 3; and Ar is phenyl or naphthyl unsubstituted or substituted with one to three substituents selected from the group consisting of hydroxy, methoxy, ethoxy, halogen, trifluoromethyl, C1 -C6 alkyl, or --NR8 R9, wherein R8 and R9 are each independently hydrogen or C1 -C6 alkyl; with the proviso that when R2 and at least one of R5 or R7 is C1 -C6 alkyl, and Ar is not substituted with trifluoromethyl or --NR8 R9, then R is --C(O)--(CH2)m --Q; or a pharmaceutically acceptable salt thereof; useful for the treatment of atherosclerosis and chronic inflammatory disorders; for inhibiting cytokine-induced expression of VCAM-1 and/or ICAM-1; for inhibiting the peroxidation of LDL lipid; for lowering plasma cholesterol; and as antioxidant chemical additives useful for preventing oxidative deterioration in organic materials.
