18861-78-4 Usage
Description
Fluorescein 6-isothiocyanate, commonly known as FITC, is an amine-reactive fluorescent probe derived from fluorescein. It is an orange solid with unique chemical properties that allow it to be used as a labeling agent for proteins and peptides. FITC is known for its strong fluorescence, which makes it a valuable tool in various applications.
Uses
Used in Biomedical Research:
Fluorescein 6-isothiocyanate is used as a fluorescent labeling reagent for proteins in biomedical research. It is particularly useful in the fluorescent antibody technique, which allows for the rapid identification of pathogens. The strong fluorescence of FITC enables researchers to easily detect and analyze the labeled proteins, making it a valuable tool in the study of various biological processes.
Used in Diagnostic Applications:
In the field of diagnostics, Fluorescein 6-isothiocyanate is used as a fluorescent labeling reagent for proteins. It is employed in the fluorescent antibody technique for the rapid identification of pathogens, which is crucial in the timely diagnosis and treatment of various diseases. The use of FITC in this context helps to improve the accuracy and efficiency of diagnostic tests.
Used in Drug Delivery Systems:
Fluorescein 6-isothiocyanate can also be used in the development of drug delivery systems. Its fluorescent properties allow for the tracking and monitoring of drug distribution within the body, which can be particularly useful in the study of drug release mechanisms and the optimization of drug delivery strategies.
Used in Environmental Monitoring:
In environmental monitoring, Fluorescein 6-isothiocyanate can be used as a tracer to study the movement and distribution of pollutants in water systems. Its strong fluorescence makes it an ideal tool for detecting and analyzing contaminants, helping to inform strategies for environmental protection and remediation.
Used in Industrial Applications:
In industrial applications, Fluorescein 6-isothiocyanate can be used as a fluorescent labeling agent for various materials and products. Its ability to provide a visible, fluorescent marker can be useful in quality control, product identification, and other processes where visual differentiation is required.
Check Digit Verification of cas no
The CAS Registry Mumber 18861-78-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,8,6 and 1 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 18861-78:
(7*1)+(6*8)+(5*8)+(4*6)+(3*1)+(2*7)+(1*8)=144
144 % 10 = 4
So 18861-78-4 is a valid CAS Registry Number.
InChI:InChI=1/C21H11NO5S/c23-12-2-5-15-18(8-12)26-19-9-13(24)3-6-16(19)21(15)17-7-11(22-10-28)1-4-14(17)20(25)27-21/h1-9,23-24H
18861-78-4Relevant articles and documents
Fluorescent human EP3 receptor antagonists
Tomasch, Miriam,Schwed, J. Stephan,Kuczka, Karina,Meyer Dos Santos, Sascha,Harder, Sebastian,Nuesing, Rolf M.,Paulke, Alexander,Stark, Holger
supporting information, p. 774 - 779 (2012/11/13)
Exchange of the lipophilc part of ortho-substituted cinnamic acid lead structures with different small molecule fluorophoric moieties via a dimethylene spacer resulted in hEP3R ligands with affinities in the nanomolar concentration range. Synthesized compounds emit fluorescence in the blue, green, and red range of light and have been tested concerning their potential as a pharmacological tool. hEP3Rs were visualized by confocal laser scanning microscopy on HT-29 cells, on murine kidney tissues, and on human brain tissues and functionally were characterized as antagonists on human platelets. Inhibition of PGE2 and collagen-induced platelet aggregation was measured after preincubation with novel hEP3R ligands. The pyryllium-labeled ligand 8 has been shown as one of the most promising structures, displaying a useful fluorescence and highly affine hEP3R antagonists.
