18867-43-1

Basic information

• Product Name: (R)-(-)-2-AMINO-1-PHENYLETHANOL HCL
• Synonyms: (R)-(-)-2-AMINO-1-PHENYLETHANOL HCL;(1R)-2-amino-1-phenylethanol,hydrochloride
• CAS NO: 18867-43-1
• Molecular Formula: C₈H₁₁NO*ClH
• Molecular Weight: 0
• EINECS: 1308068-626-2
• Mol File: 18867-43-1.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (R)-(-)-2-AMINO-1-PHENYLETHANOL HCL(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(-)-2-AMINO-1-PHENYLETHANOL HCL(18867-43-1)
• EPA Substance Registry System: (R)-(-)-2-AMINO-1-PHENYLETHANOL HCL(18867-43-1)

Safety Data

• Hazardous Substances Data: 18867-43-1(Hazardous Substances Data)

Usage

General Description

(R)-(-)-2-AMINO-1-PHENYLETHANOL HCL is a chemical compound that is the hydrochloride salt of the enantiomer (R)-(-)-2-amino-1-phenylethanol. It is commonly used as a chiral building block in the synthesis of pharmaceuticals and other organic compounds. (R)-(-)-2-AMINO-1-PHENYLETHANOL HCL is known for its role in asymmetric synthesis, where it serves as a versatile starting material for the preparation of various chiral compounds. Its applications extend to the production of chiral ligands for asymmetric catalysis and as a resolving agent for racemic mixtures. Additionally, it has been investigated for its potential pharmacological and therapeutic properties in the treatment of various medical conditions. Overall, (R)-(-)-2-AMINO-1-PHENYLETHANOL HCL is a valuable compound in the field of organic chemistry with broad implications in drug discovery and development.

InChI:InChI=1/C8H11NO.ClH/c9-6-8(10)7-4-2-1-3-5-7;/h1-5,8,10H,6,9H2;1H/t8-;/m0./s1

Upstream product

• 5468-37-1 2-aminoacetophenone hydrochloride 
• 10020-96-9 (R)-Mandelonitrile 
• 141377-54-0 2-nitro-1-phenylethan-1-ol 
• 4561-43-7 2-amino-1-phenylethanol hydrochloride 

Downstream Products

• 2549-14-6 (R)-2-Amino-1-phenylethanol 
• 391901-45-4 YM-208876 

Relevant articles and documents

Diamine-Tethered Bis(thiourea) Organocatalyst for Asymmetric Henry Reaction

We have developed a novel multifunctional C2-symmetric biphenyl-based diamine-tethered bis(thiourea) organocatalyst, which was tested in the asymmetric Henry reaction. Under thoroughly optimized conditions, the catalyst provided exceptionally high yields and excellent enantioselectivities especially for electron-deficient aromatic and heterocyclic substrates. Due to a high affinity of the catalyst to silica gel, a simple chromatography-free nitroaldol isolation procedure was feasible. Preliminary kinetic and spectroscopic experiments were performed in order to complete the mechanistic picture of the organocatalyzed nitroaldolization process. Finally, the developed synthetic strategy was successfully applied to the catalytic enantioselective syntheses of enantiopure (S)-econazole and (R)-mirabegron a late-stage intermediate.

Asymmetric Hydrogenation of α, β, and γ-Aminoketones Catalyzed by Cationic Rhodium(I){AMPP} Complexes

The chiral cationic rhodium aminophosphine-phosphinite complexes 4-6 were applied successfully in the asymmetric hydrogenation of α- (7-9), β- (10, 11) and γ- (12) aminoketone hydrochloride derivatives leading to the corresponding aminoalcohols in up to 9

A new type of atropisomeric biphenylbisphosphine ligand, (R)-MOC-BIMPO and its use in efficient assymetric hydrogenation of α-aminoketone and itaconic acid

A new atropisomeric biphenylbisphosphine, MOC-BIMOP, has been prepared in enantiomerically pure form and its rhodium(I) complex proved to be an efficient catalyst in the asymmetric hydrogenations of α-aminoketone hydrochloride and itaconic acid. A possibl