18869-47-1

Basic information

• Product Name: METHYL 2-AMINO-3-(4-HYDROXYPHENYL)PROPANOATE
• Synonyms: 2-AMINO-3-(4-HYDROXY-PHENYL)-PROPIONIC ACID METHYL ESTER;METHYL 2-AMINO-3-(4-HYDROXYPHENYL)PROPANOATE;RARECHEM AK VD 0017
• CAS NO: 18869-47-1
• Molecular Formula: C₁₀H₁₃NO₃
• Molecular Weight: 195.22
• Mol File: 18869-47-1.mol
• Article Data: 13

Chemical Properties

• Melting Point: 135.5 °C
• Boiling Point: 330°Cat760mmHg
• Flash Point: 153.4°C
• Appearance: /
• Density: 1.21g/cm³
• PKA: 9.80±0.15(Predicted)
• CAS DataBase Reference: METHYL 2-AMINO-3-(4-HYDROXYPHENYL)PROPANOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-AMINO-3-(4-HYDROXYPHENYL)PROPANOATE(18869-47-1)
• EPA Substance Registry System: METHYL 2-AMINO-3-(4-HYDROXYPHENYL)PROPANOATE(18869-47-1)

Safety Data

• Hazardous Substances Data: 18869-47-1(Hazardous Substances Data)

Usage

General Description

Methyl 2-amino-3-(4-hydroxyphenyl)propanoate is a chemical compound with the molecular formula C11H15NO3. It is a derivative of the amino acid phenylalanine and is commonly used as a building block in the synthesis of various pharmaceuticals and bioactive compounds. METHYL 2-AMINO-3-(4-HYDROXYPHENYL)PROPANOATE is known for its potential therapeutic properties, including antioxidant, anti-inflammatory, and analgesic effects. It has also been investigated for its potential use in the treatment of neurological disorders and cancer. Methyl 2-amino-3-(4-hydroxyphenyl)propanoate can be synthesized through various chemical reactions and is available for purchase from chemical suppliers for research and industrial applications.

Upstream product

• 67-56-1 methanol 
• 60-18-4 L-tyrosine 
• 77714-34-2 3-(4-Hydroxy-phenyl)-2-((E)-3-oxo-propenylamino)-propionic acid methyl ester 
• 77714-35-3 3-(4-Hydroxy-phenyl)-2-((E)-2-methyl-3-oxo-propenylamino)-propionic acid methyl ester 
• 7647-01-0 hydrogenchloride 
• 556-02-5 ?Tyr 
• 3417-91-2 tyrosine methyl ester hydrochloride 

Downstream Products

• 122445-73-2 N-stearoyl-DL-tyrosine methyl ester 
• 35047-20-2 2-diazo-3-(4-hydroxyphenyl)propanoic acid methyl ester 
• 18621-06-2 methyl trityltyrosinate 
• 97529-43-6 3-(4-Hydroxy-phenyl)-2-[2-(1H-indol-3-yl)-2-oxo-acetylamino]-propionic acid methyl ester 
• 89236-84-0 2-[(E)-2-(Diphenyl-phosphinoyl)-vinylamino]-3-(4-hydroxy-phenyl)-propionic acid methyl ester 
• 97529-48-1 2-[2-(5-Chloro-1H-indol-3-yl)-2-oxo-acetylamino]-3-(4-hydroxy-phenyl)-propionic acid methyl ester 
• 3410-66-0 D-tyrosine methyl ester 
• 60-18-4 L-tyrosine 
• 78807-85-9 2-(2-Acetylamino-4-phenyl-thiazole-5-sulfonylamino)-3-(4-hydroxy-phenyl)-propionic acid methyl ester 
• 97529-53-8 2-[2-(5-Bromo-1H-indol-3-yl)-2-oxo-acetylamino]-3-(4-hydroxy-phenyl)-propionic acid methyl ester 
• 97529-59-4 3-(4-Hydroxy-phenyl)-2-[2-(5-nitro-1H-indol-3-yl)-2-oxo-acetylamino]-propionic acid methyl ester 
• 59824-46-3 tyrosine 
• 67-56-1 methanol 
• 556-02-5 ?Tyr 

Relevant articles and documents

Method for synthesizing tyrosine framework type periodic mesoporous organosilicas materials

The invention relates to a method for preparing tyrosine framework type periodic mesoporous organosilicas materials. The method for synthesizing the tyrosine framework type periodic mesoporous organosilicas materials includes esterifying tyrosine in methanol by the aid of thionyl chloride; carrying out acrylation on the tyrosine by the aid of hydrazine hydrate and carrying out reaction on the tyrosine and isocyanic acid propyltriethoxysilane to obtain tyrosine organosilicas precursors; hydrolyzing the tyrosine organosilicas precursors and surfactants under acidic conditions to form PMO (periodic mesoporous organosilicas) materials; removing the surfactants from the PMO materials by means of extraction to ultimately form PMO materials with specific morphological structures. The tyrosine is used as a substrate. The methanol is used as a solvent. The method has the advantages synthesis reaction raw materials are simple and are easily available, synthesis operation is simple and convenient and is easy to implement, and the method is high in yield and low in energy consumption and is safe and inexpensive; the tyrosine framework type periodic mesoporous organosilicas materials prepared by the aid of the method have important application prospects in the fields of biosensors, catalyst carriers, adsorbents, sustained-release medicine capsules, chromatographic separation and the like.

BISAMIDE COMPOUNDS AS ALLOSTERIC EFFECTORS FOR REDUCING THE OXYGEN-BINDING AFFINITY OF HEMOGLOBIN

This invention relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof, which are allosteric effectors that reduce the oxygen-binding affinity of hemoglobin, which can enhance the efficacy of radiation therapy for cancer and which are useful for the treatment of ischemia and other conditions.

Synthesis of d,l-amino acid derivatives bearing a thiol at the β-position and their enzymatic optical resolution

Amino acids bearing a thiol group at the β-position are useful for native chemical ligation. Phenylalanine and tyrosine derivatives bearing a thiol group at the β-position were synthesized. Racemic phenylalanine and tyrosine were selected as starting materials and were introduced a bromo atom at the β-position by photoreaction. Subsequent substitution reaction of the bromo atom with p-methoxybenzylmercaptan yielded the corresponding amino acids bearing a thiol group at the β-position. Enzymatic optical resolution using l-aminoacylase and subsequent chemical conversion gave the corresponding optically pure l- and d-phenylalanine and tyrosine derivatives bearing a thiol group at the β-position.