18877-64-0 Usage
Description
Palmitoyl-L-carnitine chloride is a long-chain fatty ester of carnitine, a naturally occurring compound that plays a crucial role in the transport of fatty acids into the mitochondria for energy production. It is characterized by its white crystalline powder form and is accumulated and released into the circulation in fatty-acid oxidation defects. The pattern of Lauroyl-L-carnitine can be diagnostic for a number of β-oxidation defects.
Uses
Used in Diagnostic Applications:
Palmitoyl-L-carnitine chloride is used as a diagnostic tool for identifying β-oxidation defects, which are disorders that affect the body's ability to break down and utilize fatty acids for energy. The pattern of Lauroyl-L-carnitine can provide valuable information for diagnosing these conditions.
Used in Pharmaceutical Industry:
Palmitoyl-L-carnitine chloride is used as an acylcarnitine in treating cardiomyocytes for the induction of reactive oxygen species (ROS). This application is particularly relevant in the development of treatments for various cardiovascular conditions, as ROS play a significant role in the pathophysiology of these diseases.
Used in Cosmetics Industry:
Although not explicitly mentioned in the provided materials, palmitoyl-L-carnitine chloride may also have potential applications in the cosmetics industry due to its role in energy production and fatty acid metabolism. It could potentially be used in anti-aging products or formulations aimed at improving skin health and vitality.
Biochem/physiol Actions
Long-chain acylcarnitine and well-known intermediate in mitochondrial fatty acid oxidation. Modifies myocardial levels of high-energy phosphates and free fatty acids in the heart. Increases erythroid colony formation in culture. Reduces surface negative charge of erythrocytes and myocytes. Reported to affect currents and inhibit endothelium-dependent relaxation induced by acetylcholine and substance P in a dose-dependent manner by suppressing the intracellular calcium signal transduction in endothelial cells. Inhibits the Na/K pump current but has no effect on the intracellular calcium current in guinea pig ventricular cells. However, like oubain, it reversibly depolarizes the resting membrane, decreases action potential duration, and increases the amplitude of myocyte contractions.
Check Digit Verification of cas no
The CAS Registry Mumber 18877-64-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,8,7 and 7 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 18877-64:
(7*1)+(6*8)+(5*8)+(4*7)+(3*7)+(2*6)+(1*4)=160
160 % 10 = 0
So 18877-64-0 is a valid CAS Registry Number.
InChI:InChI=1/C23H45NO4.ClH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4;/h21H,5-20H2,1-4H3;1H/t21-;/m1./s1
