188820-20-4

Basic information

• Product Name: 5-Pyrimidinecarboxylic acid, 2-amino-1,4-dihydro-4,6-diphenyl-, ethyl ester
• CAS NO: 188820-20-4
• Molecular Formula: C19H19N3O2
• Molecular Weight: 321.379
• Mol File: 188820-20-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-Pyrimidinecarboxylic acid, 2-amino-1,4-dihydro-4,6-diphenyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Pyrimidinecarboxylic acid, 2-amino-1,4-dihydro-4,6-diphenyl-, ethyl ester(188820-20-4)
• EPA Substance Registry System: 5-Pyrimidinecarboxylic acid, 2-amino-1,4-dihydro-4,6-diphenyl-, ethyl ester(188820-20-4)

Safety Data

• Hazardous Substances Data: 188820-20-4(Hazardous Substances Data)

Upstream product

• 50-01-1 guanidine hydrochloride 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 100-52-7 benzaldehyde 
• 17451-18-2 (Z)-2-benzoyl-3-phenylacrylic acid ethyl ester 

Downstream Products

• 1449242-30-1 ethyl 2,4,8-triphenyl-4H-pyrimido[1,2-a]pyrimidine-3-carboxylate 
• 1449242-26-5 ethyl 8-methyl-2,4-diphenyl-4H-pyrimido[1,2-a]pyrimidine-3-carboxylate 
• 1449242-29-8 ethyl 8-(benzofuran-2-yl)-2,4-diphenyl-4H-pyrimido[1,2-a]pyrimidine-3-carboxylate 
• 1449242-28-7 ethyl 8-(1H-indol-2-yl)-2,4-diphenyl-4H-pyrimido[1,2-a]pyrimidine-3-carboxylate 
• 1449242-25-4 ethyl 2,4-diphenyl-4H-pyrimido[1,2-a]pyrimidine-3-carboxylate 
• 1449242-20-9 ethyl 2-amino-4,6-diphenyl-1,4-dihydropyrimidine-5-carboxylate hydrochloride 
• 1449242-38-9 ethyl 4-amino-2-morpholino-6,8-diphenyl-6H-pyrimido[1,2-a][1,3,5]triazine-7-carboxylate 
• 1449242-33-4 ethyl 2,4-diphenyl-8-(4-(trifluoromethyl)phenyl)-4H-pyrimido[1,2-a]pyrimidine-3-carboxylate 
• 1449242-32-3 ethyl 8-(4-methoxyphenyl)-2,4-diphenyl-4H-pyrimido[1,2-a]pyrimidine-3-carboxylate 
• 1449242-40-3 ethyl 4-oxo-6,8-diphenyl-3,4,6,9-tetrahydropyrimido[2,1-c][1,2,4,6]thiatriazine-7-carboxylate 2,2-dioxide 

Relevant articles and documents

Condensation reactions of guanidines with bis-electrophiles: Formation of highly nitrogenous heterocycles

2-Amino-1,4-dihydropyrimidines were reacted with bis-electrophiles to produce novel fused bipyrimidine, pyrimidoaminotriazine, and pyrimidosulfonamide scaffolds. In addition, a quinazoline library was constructed using a guanidine Atwal-Biginelli reaction with 1-(quinazolin-2-yl)guanidines. The product heterocycles have novel constitutions with high nitrogen atom counts and represent valuable additions to screening libraries for the discovery of new modulators of biological targets.

Synthesis of Ethyl 2-Aminodihydro-5-pyrimidinecarboxylate Derivatives and 3,7-Diethoxycarbonyl-4,6-dihydro-2,4,6,8-tetraaryl-lH-pyrimido[1,2-a]pyrimidines

Reactions of ethyl 3-aryl-2-benZoylpropenoateS 1 with guanidine and N-alkyl(or benzyl)guanidines have been investigated. Ethyl 2-aminodihydro-5-pyrimidinecarboxylate derivatives 3, 4 or 5 and 3,7-diethoxycarbonyl-4,6-dihydro-2,4,6,8-tetraaryl-lH-pyrimido[