1890-25-1Relevant articles and documents
Mn(III)-Based Oxidative Fragmentation-Cyclization Reactions of Unsaturated Cyclobutanols
Snider, Barry B.,Vo, Nha Huu,Foxman, Bruce M.
, p. 7228 - 7237 (1993)
Alylic cyclobutanols 1, 10, 21, 27, 32, 39, 51 and 58 are oxidatively fragmented by Mn(OAc)3*2H2O in EtOH to give tertiary radicals as shown in eq 1.These tertiary radicals undergo both 6-endo-cyclization to the α,β-unsaturated ketone to afford α-keto rad
GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE
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, (2021/01/22)
Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with a defect in glyoxylate metabolism, for example a disease or disorder associated with the enzyme glycolate oxidase (GO) or alterations in oxalate metabolism. Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.
Pichia stipitis OYE 2.6 variants with improved catalytic efficiencies from site-saturation mutagenesis libraries
Patterson-Orazem, Athéna,Sullivan, Bradford,Stewart, Jon D.
, p. 5628 - 5632 (2015/01/09)
An earlier directed evolution project using alkene reductase OYE 2.6 from Pichia stipitis yielded 13 active site variants with improved properties toward three homologous Baylis-Hillman adducts. Here, we probed the generality of these improvements by testing the wild-type and all 13 variants against a panel of 16 structurally-diverse electron-deficient alkenes. Several substrates were sterically demanding, and as hoped, creating additional active site volume yielded better conversions for these alkenes. The most impressive improvement was found for 2-butylidenecyclohexanone. The wild-type provided less than 20% conversion after 24 h; a triple mutant afforded more than 60% conversion in the same time period. Moreover, even wild-type OYE 2.6 can reduce cyclohexenones with very bulky 4-substituents efficiently.
