189065-48-3

Basic information

• Product Name: N-methyl-N-phenyl-3-(trifluoromethyl)aniline
• Synonyms: N-methyl-N-phenyl-3-(trifluoromethyl)aniline
• CAS NO: 189065-48-3
• Molecular Formula: C14H12F3N
• Molecular Weight: 251.2469896
• Mol File: 189065-48-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-methyl-N-phenyl-3-(trifluoromethyl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-N-phenyl-3-(trifluoromethyl)aniline(189065-48-3)
• EPA Substance Registry System: N-methyl-N-phenyl-3-(trifluoromethyl)aniline(189065-48-3)

Safety Data

• Hazardous Substances Data: 189065-48-3(Hazardous Substances Data)

Usage

General Description

N-methyl-N-phenyl-3-(trifluoromethyl)aniline is a chemical compound with the chemical formula C16H14F3N. It is an aromatic amine that contains a methyl group, a phenyl group, and a trifluoromethyl group attached to the nitrogen atom. N-methyl-N-phenyl-3-(trifluoromethyl)aniline is commonly used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and dyes. It is also used as a reagent for the preparation of various organic compounds. N-methyl-N-phenyl-3-(trifluoromethyl)aniline is a crystalline solid with a strong odor, and it is important to handle it with care due to its potential hazards.

Upstream product

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Relevant articles and documents

Carbene adduct of cyclopalladated ferrocenylimine as an efficient catalyst for the amination of aryl chlorides

A novel air- and moisture-stable carbene adduct of cyclopalladated ferrocenylimine has been synthesized and characterized. The structure of this compound was determined by X-ray crystal structure analysis. This adduct has been applied as an efficient catalyst for the amination of aryl chlorides.

New ligands for a general palladium-catalyzed amination of aryl and heteroaryl chlorides

The synthesis and application of monodentate N-substituted heteroarylphosphines is described. In general, the ligands are conveniently prepared by selective metallation at the 2-position of the respective N-substituted heterocycle (pyrrole, indole) by using n-butyllithium/ tetramethylethylenediamine (TMEDA) followed by quenching with dialkyl- or diarylchlorophosphines. Of the different ligands prepared, the new dialkyl-2-(N-arylindolyl)phosphines (cataCXium P) perform excellently in the palladium-catalyzed amination of aryl and heteroaryl chlorides. Coupling of both activated and deactivated chloroarenes proceeds under mild conditions (room temperature to 60°C). By using optimized conditions remarkable catalyst productivity (total turnover number, TON, up to 8000) and activity (turnover frequency, TOF = 14000 h-1 at 75% conversion) are observed.

First palladium-catalyzed aminations of aryl chlorides

The palladium-catalyzed coupling reaction of aryl chlorides with various amines has been studied for the first time. Crucial for the success of this C-N bond forming reaction is the use of potassium tert-butoxide as base. Turn over numbers up to 900 and y