18910-70-8

Basic information

• Product Name: Levalbuterol Related Compound C (30 mg) (alpha-[{(1,1-Dimethylethyl)amino}methyl]-4-hydroxy-3-(methoxymethyl)-benzenemethanol)
• Synonyms: (R)-4-(2-(tert-butylamino)-1-hydroxyethyl)-2-(methoxymethyl)phenol;Levalbuterol Related Compound C (30 mg) (alpha-[{(1,1-Dimethylethyl)amino}methyl]-4-hydroxy-3-(methoxymethyl)-benzenemethanol);O-Methyl Albuterol;Levalbuterol Related CoMpound C;Salbutamol Impurity M;4-(2-(tert-butylamino)-1-hydroxyethyl)-2-(methoxymethyl)phenol;Salbutamol EP Impurity M
• CAS NO: 18910-70-8
• Molecular Formula: C₁₄H₂₃NO₃
• Molecular Weight: 253.33732
• Mol File: 18910-70-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 402.2±40.0 °C(Predicted)
• Appearance: /
• Density: 1.087±0.06 g/cm3(Predicted)
• PKA: 9.53±0.50(Predicted)
• CAS DataBase Reference: Levalbuterol Related Compound C (30 mg) (alpha-[{(1,1-Dimethylethyl)amino}methyl]-4-hydroxy-3-(methoxymethyl)-benzenemethanol)(CAS DataBase Reference)
• NIST Chemistry Reference: Levalbuterol Related Compound C (30 mg) (alpha-[{(1,1-Dimethylethyl)amino}methyl]-4-hydroxy-3-(methoxymethyl)-benzenemethanol)(18910-70-8)
• EPA Substance Registry System: Levalbuterol Related Compound C (30 mg) (alpha-[{(1,1-Dimethylethyl)amino}methyl]-4-hydroxy-3-(methoxymethyl)-benzenemethanol)(18910-70-8)

Safety Data

• Hazardous Substances Data: 18910-70-8(Hazardous Substances Data)

Usage

Description

Levalbuterol Related Compound C (30 mg) (alpha-[(1,1-Dimethylethyl)aminomethyl]-4-hydroxy-3-(methoxymethyl)-benzenemethanol) is a synthetic compound that serves as an impurity in the synthesis of Albuterol (A514501). It is derived from the racemic mixture of Albuterol, which is a β2-adrenoceptor agonist with bronchodilator and tocolytic properties.

Uses

Used in Pharmaceutical Industry:
Levalbuterol Related Compound C (30 mg) (alpha-[(1,1-Dimethylethyl)aminomethyl]-4-hydroxy-3-(methoxymethyl)-benzenemethanol) is used as an impurity in the synthesis of Albuterol for its role as a β2-adrenoceptor agonist. This application is crucial in the development and production of bronchodilator and tocolytic medications, which are essential for treating respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD), as well as for managing preterm labor.
In addition to its role in the pharmaceutical industry, Levalbuterol Related Compound C may also have potential applications in research and development, where it can be used to study the effects of Albuterol and its derivatives on various biological systems. This can contribute to the advancement of new therapeutic strategies and the improvement of existing treatments for respiratory and obstetric conditions.

Upstream product

• 67-56-1 methanol 
• 348135-26-2 (R)-α1-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-1,3-benzenedimethanol D-dibenzoyltartrate 

Relevant articles and documents

Preparation of levalbuterol hydrochloride

Provided are processes for the preparation of (R)-SLB.D-DBTA salt and levalbuterol hydrochloride. Also provided are levalbuterol hydrochloride degradation products and processes for preparing them. Pharmaceutical compositions comprising at least one levalbuterol hydrochloride of the invention and at least one pharmaceutically-acceptable excipient are also provided.