18912-81-7

Basic information

• Product Name: C5E2
• Synonyms: PENTYLDIGLYCOL;N-PENTYLDIOXYETHYLENE;C5E2;DIETHYLENEGLYCOLMONOPENTYL ETHER;2-(2-PENTYLOXYETHOXY)ETHANOL;Ethanol, 2-2-(pentyloxy)ethoxy-;2-(2-Pentyloxyethoxy)ethanol, C5E2, Pentyldiglycol;1,4,7-Trioxadodecane
• CAS NO: 18912-81-7
• Molecular Formula: C₉H₂₀O₃
• Molecular Weight: 176.25
• Mol File: 18912-81-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 255°C at 760 mmHg
• Flash Point: 110 °C
• Appearance: /
• Density: 0.942 g/mL at 20 °C(lit.)
• Vapor Pressure: 0.00254mmHg at 25°C
• Refractive Index: n20/D 1.435
• Storage Temp.: 2-8°C
• CAS DataBase Reference: C5E2(CAS DataBase Reference)
• NIST Chemistry Reference: C5E2(18912-81-7)
• EPA Substance Registry System: C5E2(18912-81-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 10-23
• Hazardous Substances Data: 18912-81-7(Hazardous Substances Data)

Usage

Description

C5E2, also known as Diethylene Glycol Monopentyl Ether, is a compound that has been considered for various applications due to its unique properties. It is particularly noted for its potential use in the pharmaceutical industry, specifically for the delivery of peptide-based pharmaceuticals to the respiratory tract.

Uses

Used in Pharmaceutical Industry:
C5E2 is used as a propellant-solution surfactant for the delivery of peptide-based pharmaceuticals to the respiratory tract. Its properties make it a promising candidate for enhancing the effectiveness of such medications, particularly in cases where direct and targeted delivery is required.

InChI:InChI=1/C9H20O3/c1-2-3-4-6-11-8-9-12-7-5-10/h10H,2-9H2,1H3

Upstream product

• 110-53-2 1-Bromopentane 
• 111-46-6 diethylene glycol 
• 71-41-0 pentan-1-ol 
• 75-21-8 oxirane 
• 6196-58-3 2-(pentyloxy)ethanol 

Relevant articles and documents

PYRROLO[2,3-B]PYRIDIN DERIVATIVES AS INHIBITORS OF INFLUENZA VIRUS REPLICATION

Provided herein are compounds of Formula A, B or C that can inhibit the replication of influenza viruses, reduce the amount of influenza viruses, and/or treat influenza.

Combinatorial synthesis of PEG oligomer libraries

A simple chain-extending approach was established for the scale-up of the monoprotected monodisperse PEG diol materials. Reactions of THP-(OCH2CH2)n—OMs (n=4, 8, 12) with a large excess of commercially available H—(OCH2CH2)n—OH (n=1-4) under basic conditions led to THP-(OCH2CH2)n—OH (n=5-15). Similarly, Me-(OCH2CH2)n—OH (n=4-11, 13) were prepared from Me-(OCH2CH2)n—OMs (n=3, 7, 11). For the chain elongation steps, 40-80% yields were achieved through extraction purification. PEG oligomer libraries I and II were generated in 50-95% overall yields by alkylation or acylation of THP-(OCH2CH2)n—OH (n=1-15) followed by deprotection. Alkylation of Me-(OCH2CH2)n—OH (n=1-11, 13) with X—(CH2)m—CO2R (X=Br or OMs) and subsequent hydrolysis led to PEG oligomer library III in 30-60% overall yields. Combinatorial purification techniques were adapted to the larger-scale library synthesis. A total of 498 compounds, each with a weight of 2-5 g and a minimum purity of 90%, were synthesized.