189130-24-3

Basic information

• Product Name: (2S)-2-(2-fluoro-biphenyl-4-yl)-propan-1-ol
• Synonyms: (2S)-2-(2-fluoro-biphenyl-4-yl)-propan-1-ol
• CAS NO: 189130-24-3
• Molecular Weight: 230.282
• Mol File: 189130-24-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S)-2-(2-fluoro-biphenyl-4-yl)-propan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-2-(2-fluoro-biphenyl-4-yl)-propan-1-ol(189130-24-3)
• EPA Substance Registry System: (2S)-2-(2-fluoro-biphenyl-4-yl)-propan-1-ol(189130-24-3)

Safety Data

• Hazardous Substances Data: 189130-24-3(Hazardous Substances Data)

Upstream product

• 56430-76-3 2-(2-fluoro-biphenyl-4-yl)-propionaldehyde 

Downstream Products

• 42771-79-9 3'-fluoro-4'-phenylacetophenone 
• 5104-49-4 (S)-(+)-flurbiprofen 

Relevant articles and documents

Chemoenzymatic synthesis of (2S)-2-arylpropanols through a dynamic kinetic resolution of 2-arylpropanals with alcohol dehydrogenases

We applied Horse Liver Alcohol Dehydrogenase (HLADH) to the enantioselective synthesis of six (2S)-2-arylpropanols, useful intermediates in the synthesis of Profens. The influence of substrate structure and reaction conditions on yields and enantioselectivity were investigated. The high yields and high enantioselectivity towards the (S)-enantiomer obtained in the bioreduction of 2-arylpropionic aldehydes, clearly indicate the achievement of a DKR process through a combination of an enzyme-catalyzed kinetic reduction with a chemical base-catalyzed racemization of the unreacted aldehydes. The racemization step is represented by the keto-enol equilibrium of the aldehyde and can be controlled by modulating pH and reaction conditions.