189161-09-9

Basic information

• Product Name: 3-Chloro-5-methylbenzonitrile
• Synonyms: 3-Chloro-5-methylbenzonitrile
• CAS NO: 189161-09-9
• Molecular Formula: C₈H₆ClN
• Molecular Weight: 151.59294
• Mol File: 189161-09-9.mol
• Article Data: 7

Chemical Properties

• Melting Point: 61-63 °C
• Boiling Point: 237.6±20.0 °C(Predicted)
• Appearance: /
• Density: 1.19±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-Chloro-5-methylbenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-5-methylbenzonitrile(189161-09-9)
• EPA Substance Registry System: 3-Chloro-5-methylbenzonitrile(189161-09-9)

Safety Data

• Hazardous Substances Data: 189161-09-9(Hazardous Substances Data)

Usage

Chemical Properties

off-white crytalline

InChI:InChI=1S/C8H6ClN/c1-6-2-7(5-10)4-8(9)3-6/h2-4H,1H3

Upstream product

• 557-21-1 zinc(II) cyanide 
• 502630-89-9 2-(3-chloro-5-methylphenyl)-4,4,5,5-tetra methyl-1,3,2-dioxaborolane 
• 329944-72-1 1-bromo-3-chloro-5-methylbenzene 
• 103426-20-6 3-chloro-5-methylbenzaldehyde 

Downstream Products

• 1021871-36-2 3-(bromomethyl)-5-chlorobenzonitrile 
• 176548-88-2 1-(3-chloro-5-methylphenyl)ethanone 
• 1240305-88-7 3-chloro-5-methylbenzamide 
• 1240305-91-2 3-chloro-5-methylbenzylamine 
• 1240305-93-4 5-(3-chloro-5-methylphenyl)-1H-tetrazole 
• 56961-33-2 3-Chloro-5-Methylbenzoic Acid 
• 103426-20-6 3-chloro-5-methylbenzaldehyde 
• 1027488-95-4 2-(3-Chloro-5-methyl-phenyl)-1-(4-methanesulfonyl-phenyl)-4-trifluoromethyl-4,5-dihydro-1H-imidazol-4-ol 
• 177661-14-2 4-[2-(3-chloro-5-methylphenyl)-4-(trifluoromethyl)-1H-imidazol-1-yl]benzenesulfonamide 
• 177661-46-0 2-(3-chloro-5-methylphenyl)-1-[4-(methylsulfonyl)phenyl]-4-(trifluoromethyl)-1H-imidazole 

Relevant articles and documents

Palladium-Catalyzed Cyanation under Mild Conditions: A Case Study to Discover Appropriate Substrates among Halides and Pseudohalides

A case study has been effectively carried out to identify a suitable substrate among halides and pseudohalides for the palladium-catalyzed cyanation reactions under mild conditions. Among the various substrates considered for evaluation, aryl pentafluorobenzenesulfonates and nonaflates were identified to be the best substrates when compared to corresponding halides and pseudohalides. The substoichiometric use of nontoxic, environmentally benign potassium hexacyanoferrate as a cyanide source and exceptionally milder conditions further highlights the significance of the protocol developed. A wide range of electronically biased and sterically challenging substrates provided the corresponding the nitriles in good to excellent yields.

COMPOUNDS AND USES THEREOF

The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

PYRIDONE DERIVATIVES AS NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS

The present invention relates to 2-pyridone derivatives of Formula (I) or (IV) as herein described, compositions containing such compounds, synthetic processes for making such compounds, and therapeutic methods that include the administration of such comp