189345-04-8 Usage
Description
(6R,7R)-7-[(Z)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(ethoxyimino)acetamido]-3-[4-(1-methylpyridinium-4-yl)thiazol-2-ylsulfanyl]-3-cephem-4-carboxylate is a complex cephalosporin-based compound with a unique combination of chemical moieties, including a thiazole ring, a 1,2,4-thiadiazol ring, an ethoxyiminoacetamido side chain, and a pyridinium group. This molecule is likely to exhibit potent antibiotic properties and additional pharmacological activities due to its diverse structural components.
Uses
Used in Pharmaceutical Industry:
(6R,7R)-7-[(Z)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(ethoxyimino)acetamido]-3-[4-(1-methylpyridinium-4-yl)thiazol-2-ylsulfanyl]-3-cephem-4-carboxylate is used as an antibiotic agent for the treatment of bacterial infections. Its cephalosporin core and the presence of a 1,2,4-thiadiazol ring may contribute to its potency and selectivity against a range of bacterial pathogens.
Used in Research and Development:
In the field of medicinal chemistry and pharmaceutical research, this compound serves as a valuable research tool for understanding the structure-activity relationships of cephalosporin-based antibiotics and exploring the potential synergistic effects of its various chemical moieties. This knowledge can be applied to the design and development of new, more effective, and targeted antibiotics.
Used in Drug Resistance Studies:
(6R,7R)-7-[(Z)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(ethoxyimino)acetamido]-3-[4-(1-methylpyridinium-4-yl)thiazol-2-ylsulfanyl]-3-cephem-4-carboxylate can be employed in studies aimed at understanding and overcoming antibiotic resistance in bacteria. Its unique structural features may provide insights into new strategies for combating resistant strains and developing novel therapeutic approaches.
Used in Drug Delivery Systems:
Similar to gallotannin, this complex cephalosporin compound may also benefit from novel drug delivery systems to enhance its bioavailability, delivery, and therapeutic outcomes. Researchers can explore various organic and metallic nanoparticles as carriers for improved administration and targeting of bacterial infections.
Check Digit Verification of cas no
The CAS Registry Mumber 189345-04-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,9,3,4 and 5 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 189345-04:
(8*1)+(7*8)+(6*9)+(5*3)+(4*4)+(3*5)+(2*0)+(1*4)=168
168 % 10 = 8
So 189345-04-8 is a valid CAS Registry Number.
189345-04-8Relevant articles and documents
TAK-599, a novel N-phosphono type prodrug of anti-MRSA cephalosporin T-91825: Synthesis, physicochemical and pharmacological properties
Ishikawa, Tomoyasu,Matsunaga, Nobuyuki,Tawada, Hiroyuki,Kuroda, Noritaka,Nakayama, Yutaka,Ishibashi, Yukio,Tomimoto, Mitsumi,Ikeda, Yukihiro,Tagawa, Yoshihiko,Iizawa, Yuji,Okonogi, Kenji,Hashiguchi, Shohei,Miyake, Akio
, p. 2427 - 2437 (2007/10/03)
Crystalline 1 (TAK-599) is a novel N-phosphono prodrug of anti-methicillin-resistant Staphylococcus aureus (MRSA) cephalosporin 2a (T-91825) that has high affinity for penicillin-binding protein (PBP) 2′ (IC50; 0.90 μg/mL) and shows potent in v
