18942-90-0Relevant articles and documents
Enzymatic synthesis of optical pure β-nitroalcohols by combining d-aminoacylase-catalyzed nitroaldol reaction and immobilized lipase PS-catalyzed kinetic resolution
Xu, Fan,Wang, Junliang,Liu, Bokai,Wu, Qi,Lin, Xianfu
, p. 2359 - 2361 (2011/10/19)
An enzymatic method which combines d-aminoacylase catalyzed nitroaldol reaction and lipase PS-IM catalyzed acyl resolution reaction was constructed to obtain optically pure β-nitroalcohols in organic media under mild conditions. A series of β-nitroalcohols were synthesized and then resolved, with excellent ee values (>95%) and yields mostly, giving enantiomerically pure acetate and alcohol of the opposite configuration simultaneously.
Metal-directed Synthesis of Aminobenzyl Polyaza Macrocycles: Candidates for Attachment to Polymers and Biomolecules
Bayada, Anne,Lawrance, Geoffrey A.,Maeder, Marcel,O'Leary, Margaret A.
, p. 3107 - 3112 (2007/10/02)
Copper(II)-directed condensation between 4,7-diazadecane-1,10-diamine, formaldehyde and 1-nitro-3-(2-nitroethyl)benzene yielded the macrocyclic copper(II) ion.Reduction (Zn,HCl) gave the pendant-arm macrocycle 10-(3-aminobenzyl)-1,4,8,12-tetraazacyclopentadec-10-ylamine as the hydrochloride salt.Condensation reactions with 1-nitro-4-(2-nitroethyl)benzene and 2-phenylnitroethane were also successful.The capacity of the aminobenzyl C-pendant introduced by this facile chemistry for covalent attachment has been examined by attachment of 10-(3-aminobenzyl)-1,4,8,12-tetraazacyclopentadec-10-ylamine to the acidic cation-exchange resin CM Bio-Gel A and to horse heart cytochrome c, employing a water-soluble carbodiimide coupling agent at pH 5 to promote amide formation.The attachment was probed by copper(II) complexation to the bound macrocycle and subsequent spectroscopic or voltammetric analysis.
A Highly Chemoselective Reduction of Conjugated Nitro Olefins with Hantzsch Ester in the Presence of Silica Gel
FUJI, Masayuki
, p. 4029 - 4036 (2007/10/02)
An effective system to reduce conjugated nitro olefins into the corresponding nitroalkanes is described.The system composed Hantzsch ester (HEH) and silica gel in benzene exerts high yield and excellent chemoselectivity under almost neutral conditions.Facile applications of the system to the syntheses of natural products are also described.